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doi:10.1155/2012/295906 Research Article Application of Mild Therapeutic Hypothermia on Stroke: A Systematic Review and Meta-Analysis (2011)
BibTeX
@MISC{Lakhan11doi:10.1155/2012/295906research,
author = {Shaheen E. Lakhan and Fabricio Pamplona},
title = {doi:10.1155/2012/295906 Research Article Application of Mild Therapeutic Hypothermia on Stroke: A Systematic Review and Meta-Analysis},
year = {2011}
}
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Abstract
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Stroke occurs due to an interruption in cerebral blood supply affecting neuronal function. Body temperature on hospital admission is an important predictor of clinical outcome. Therapeutic hypothermia is promising in clinical settings for stroke neuroprotection. Methods. MEDLINE/PubMed, CENTRAL, Stroke Center, and ClinicalTrials.gov were systematically searched for hypothermia intervention induced by external or endovascular cooling for acute stroke. NIH Stroke Scale (NIHSS) and modified Rankin Scale (mRS) were the main stroke scales used, and mortality was also reported. A meta-analysis was carried out on stroke severity and mortality. Results. Seven parallel-controlled clinical trials were included in the meta-analysis. Sample sizes ranged from 18 to 62 patients, yielding a total of 288. Target temperature (∼33 ◦ C) was reached within 3-4 hours. Stroke
Keyphrases
systematic review mild therapeutic hypothermia research article application acute stroke original work seven parallel-controlled clinical trial stroke center cerebral blood supply hypothermia intervention stroke severity hospital admission 3-4 hour neuronal function clinical setting endovascular cooling important predictor main stroke scale unrestricted use medline pubmed nih stroke scale body temperature clinical outcome rankin scale therapeutic hypothermia stroke neuroprotection attribution license
