@MISC{_researcharticle, author = {}, title = {RESEARCH ARTICLE Open Access}, year = {} }
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Abstract
Research article The anti-cyclic citrullinated peptide response in tuberculosis patients is not citrulline-dependent and sensitive to treatment Ori Elkayam * †1, Refael Segal †2, Daniele Bendayan 3, Robert van Uitert 4, Carla Onnekink 5 and Ger JM Pruijn 5 Introduction: Patients with tuberculosis (TB) frequently produce anti-citrullinated protein antibodies (ACPA). The objective of this study is to characterize the citrulline-dependence of the ACPA reactivity in sera of patients with mycobacterium infections. Methods: Serum samples of 134 patients with untreated mycobacterium infections (122 TB, 12 nontuberculous mycobacterium) were tested for antibodies against both the citrullinated (Cit) and the non-citrullinated (Arg) form of 2