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Cardiac arrhythmia induced by hypothermia in a cardiac model in vitro 1 (2013)
| Citations: | 2 - 1 self |
BibTeX
@MISC{Xu13cardiacarrhythmia,
author = {Binbin Xu and Sabir Jacquir and Stéphane Binczak and Oriol Pont and Hussein Yahia},
title = {Cardiac arrhythmia induced by hypothermia in a cardiac model in vitro 1},
year = {2013}
}
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Abstract
Abstract. Patients that have survived Out-of-Hospital Cardiac Arrest usually develop some degree of neurological problems. A common treatment to mitigate neurological damage is mild therapeutic hypothermia (MTH). However, MTH has adverse effects, including arrhythmia. In order to explore the mechanisms of arrhythmia linked to MTH, we took measures on a temperature controlled experimental model which simulates MTH. These measures consisted of extracellular potential of cardiac culture on a multi-electrode array and we analysed them in terms of nonlinear dynamics. The results showed that cardiac arrhythmia is induced around temperature 35°C (spiral waves at T~35°C against plane waves at other temperatures). A period-doubling phenomenon is also observed around T=35°C, confirmed with the analysis methods. All results showed that 35°C is a critical temperature triggering arrhythmia. This suggests that the re-warming / cooling speed could affect the arrhythmia generation after MTH.
Keyphrases
cardiac arrhythmia cardiac model critical temperature arrhythmia generation neurological problem adverse effect multi-electrode array cardiac culture period-doubling phenomenon spiral wave plane wave mild therapeutic hypothermia re-warming cooling speed analysis method common treatment neurological damage out-of-hospital cardiac arrest nonlinear dynamic extracellular potential experimental model
