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Research Article Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism
BibTeX
@MISC{Negrette-guzmán_researcharticle,
author = {Mario Negrette-guzmán and Wylly Ramsés García-niño and Edilia Tapia and Cecilia Zazueta and Sara Huerta-yepez and Juan Carlos León-contreras and Rogelio Hernández-p and Omar Emiliano Aparicio-trejo and Magdalena Madero and José Pedraza-chaverri},
title = {Research Article Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism},
year = {}
}
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Abstract
Copyright © 2015 Mario Negrette-Guzmán et al.This is an open access article distributed under theCreativeCommonsAttribution License, which permits unrestricted use, distribution, and reproduction in anymedium, provided the originalwork is properly cited. It has been shown that curcumin (CUR), a polyphenol derived from Curcuma longa, exerts a protective effect against gentamicin-(GM-) induced nephrotoxicity in rats, associatedwith a preservation of the antioxidant status. Althoughmitochondrial dysfunction is a hallmark in the GM-induced renal injury, the role of CUR inmitochondrial protection has not been studied. In this work, LLC-PK1 cells were preincubated 24 h with CUR and then coincubated 48 h with CUR and 8mMGM. Treatment with CUR attenuated GM-induced drop in cell viability and led to an increase in nuclear factor (erythroid-2)-related factor 2 (Nrf2) nuclear accumulation andperoxisomeproliferator-activated receptor gamma coactivator-1 alpha (PGC-1
