Detrimental effects of complement activation in hemorrhagic shock

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Detrimental effects of complement activation in hemorrhagic shock (2000)

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by John G. Younger , Nobuyoshi Sasaki , Michael D. Waite , Ronald B. Hirschl , Peter A. Ward , Gerd O. Till , John G , Nobuyoshi Sasaki , Michael D , Holt N. Murray , Edward F. Saleh , Zachary A , Ronald B. Hirschl , Peter A. Ward , Gerd O

Citations

36	Intravascular activation of complement and acute lung injury: dependency on neutrophils and toxic oxygen metabolites. - Till, Johnson, et al. - 1982 (Show Context) Citation Context ...or the appearance in blood of activation products) has been noted repeatedly (3, 5–8, 12, 17, 21). These observations have also been made in laboratory models of blood loss or extensive tissue injury =-=(6, 16, 18)-=-. In the present studies, we too found that severe blood loss in rats was associated with complement activation. That exposure to CVF before hemorrhage improved systemic markers of injury, whereas str...
34	Two anticomplementary factors in cobra venom: hemolysis of guinea pig erythrocytes by one of them - Ballow, Cochrane - 1969 (Show Context) Citation Context ..., St. Louis, MO) was dialyzed for 24 h against 40 mM phosphate-buffered saline and then fractionated by anion-exchange chromatography on a diethylaminoethyl cellulose column (DE52, Whatman, Kent, UK) =-=(1)-=-. Animals were given intraperitoneal injections of 25 units of CVF in 1.0 ml of saline 36, 24, and 12 h before hemorrhage. Serum CH50 and C3 levels at the onset of hemorrhage were used to confirm comp...
22	Deposition of the terminal C5b-9 complement complex in infarcted areas of human myocardium. - Schafer, Mathey, et al. - 1986 (Show Context) Citation Context ...ystemic complement activation. The complement cascade may worsen hemorrhagic shock in a variety of ways. Whereas evidence exists for a direct role of the membrane attack complex in models of ischemia =-=(14)-=-, data from other models suggest a pivotal role for C5a (2). Confirmation of the relevance of C5a in this model may only come with the availability of anti-rat C5a antibodies. Given that C5a is an 8-k...
18	Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement. - Weiser, Williams, et al. - 1996 (Show Context) Citation Context ...ations have been made in animal studies, where systemic complement activation has been described in soft tissue trauma, burn injury, and models of myocardial, intestinal, and skeletal muscle ischemia =-=(6, 9, 11, 18)-=-. Although activation occurs in the setting of severe blood loss, data implicating complement as an effector of tissue injury are limited (4). In the present studies, we used a rat model to examine he...
16	Protective effects of C5a blockade in sepsis. Nature medicine - Czermak, Sarma, et al. - 1999 (Show Context) Citation Context ...rsen hemorrhagic shock in a variety of ways. Whereas evidence exists for a direct role of the membrane attack complex in models of ischemia (14), data from other models suggest a pivotal role for C5a =-=(2)-=-. Confirmation of the relevance of C5a in this model may only come with the availability of anti-rat C5a antibodies. Given that C5a is an 8-kDa fragment of the much larger C5 protein, antibodies that ...
13	Soluble complement receptor type 1 ameliorates the local and remote organ injury after intestinal ischemia-reperfusion in the rat. - Hill, TF, et al. - 1992 (Show Context) Citation Context ...ations have been made in animal studies, where systemic complement activation has been described in soft tissue trauma, burn injury, and models of myocardial, intestinal, and skeletal muscle ischemia =-=(6, 9, 11, 18)-=-. Although activation occurs in the setting of severe blood loss, data implicating complement as an effector of tissue injury are limited (4). In the present studies, we used a rat model to examine he...
11	Circulating complement proteins in multiple trauma patients— correlation with injury severity, development of sepsis, and outcome. Crit Care Med - Hecke, Schmidt, et al. - 1997
7	Complement plays an essential role in shock following intestinal ischaemia in rats. Clin Exp Immunol - IKAI, ITOH, et al. - 1996 (Show Context) Citation Context ...ations have been made in animal studies, where systemic complement activation has been described in soft tissue trauma, burn injury, and models of myocardial, intestinal, and skeletal muscle ischemia =-=(6, 9, 11, 18)-=-. Although activation occurs in the setting of severe blood loss, data implicating complement as an effector of tissue injury are limited (4). In the present studies, we used a rat model to examine he...
7	Complement activation and the prognostic value of C3a in patients at risk of adult respiratory distress syndrome. Clin Exp Immunol 79: 151–157 - Zilow, Sturm, et al. - 1990
5	A potent mercapto bi-product analogue inhibitor for human carboxypeptidase N. - RYAN - 1981 (Show Context) Citation Context ...thyl-3-guanidinoethylthiopropanoic acid (Calbiochem, La Jolla, CA) intraperitoneally. This agent has demonstrated specificity for carboxypeptidase N and reduces serum enzyme activity by .90% for .3 h =-=(10, 13)-=-. Control animals also received CPNI after instrumentation. Preconditioning effect of complement activation. Whereas serial intraperitoneal injections of CVF deplete serum complement activity and are ...
4	Complement inhibition prevents gut ischemia and endothelial cell dysfunction after hemorrhage/resuscitation. - Fruchterman, Spain, et al. - 1998 (Show Context) Citation Context ...rdial, intestinal, and skeletal muscle ischemia (6, 9, 11, 18). Although activation occurs in the setting of severe blood loss, data implicating complement as an effector of tissue injury are limited =-=(4)-=-. In the present studies, we used a rat model to examine hemodynamic and metabolic recovery from an episode of prolonged, profound hemorrhagic hypotension. We found that hemorrhage and resuscitation a...
4	Terminal complement complexes and anaphylatoxins in septic and ischemic patients. - Heideman, Norder-Hansson, et al. - 1988
4	Hugli T. Potentiation of the anaphylatoxins in vivo using an inhibitor of serum carboxypeptidase (SCPN). I. Lethality and pathologic effects on pulmonary tissue - Huey, Bloor, et al. - 1983 (Show Context) Citation Context ...thyl-3-guanidinoethylthiopropanoic acid (Calbiochem, La Jolla, CA) intraperitoneally. This agent has demonstrated specificity for carboxypeptidase N and reduces serum enzyme activity by .90% for .3 h =-=(10, 13)-=-. Control animals also received CPNI after instrumentation. Preconditioning effect of complement activation. Whereas serial intraperitoneal injections of CVF deplete serum complement activity and are ...
3	Accentuated formation of the terminal C5b-9 complement complex in patient plasma precedes development of the adult respiratory distress syndrome. Am Rev Respir Dis 138: 368–375 - Langlois, Gawryl - 1988
2	Complement activation and hematologic, hemodynamic, and respiratory reactions early after soft-tissue injury - Heideman, Kaijser, et al. - 1978 (Show Context) Citation Context ...ations have been made in animal studies, where systemic complement activation has been described in soft tissue trauma, burn injury, and models of myocardial, intestinal, and skeletal muscle ischemia =-=(6, 9, 11, 18)-=-. Although activation occurs in the setting of severe blood loss, data implicating complement as an effector of tissue injury are limited (4). In the present studies, we used a rat model to examine he...
2	Complement studies of sera and other biological fluids. Hum Pathol 14: 338–342 - Schur - 1983 (Show Context) Citation Context ...ere measured at baseline, before and after resuscitation, and at the conclusion of the experiment. Total serum hemolytic activity was measured by using the total hemolytic complement (CH50) technique =-=(15)-=-. Serial dilutions of serum were incubated for 1 h at 37°C with sheep erythrocytes (Colorado Serum, Denver, CO) that had been sensitized with rabbit anti-sheep hemolysin (Colorado Serum). The reciproc...
1	Complement activation following multiple injuries. Acta Chir Scand 153: 325–330 - Fosse, Mollnes, et al. - 1987
1	Effect of nonviable tissue and abscesses on complement depletion and the development of bacteremia - Heideman, Saravis, et al. - 1982
1	Complement and the severity of pulmonary failure - Weigelt, Chenoweth, et al. - 1988
1	The pattern of early lung parenchymal and airspace injury following acute blood loss. Acad Emerg Med 5: 659–665 - Younger, Taqi, et al. (Show Context) Citation Context ...f serum carboxypeptidase N activity, exacerbates injury. METHODS Rat model of hemorrhagic shock. A fixed-pressure hemorrhagic shock model was used in all experiments and has been described previously =-=(19, 20)-=-. Male, specific pathogen-free Sprague-Dawley rats were anesthetized with subcutaneous ketamine hydrochloride (50 mg/kg) and xylazine hydrochloride (10 mg/kg). With animals in a supine position, a tra...
1	Hirschl RB. Partial liquid ventilation protects lung during resuscitation from hemorrhagic shock - JG, AS, et al. - 1997 (Show Context) Citation Context ...f serum carboxypeptidase N activity, exacerbates injury. METHODS Rat model of hemorrhagic shock. A fixed-pressure hemorrhagic shock model was used in all experiments and has been described previously =-=(19, 20)-=-. Male, specific pathogen-free Sprague-Dawley rats were anesthetized with subcutaneous ketamine hydrochloride (50 mg/kg) and xylazine hydrochloride (10 mg/kg). With animals in a supine position, a tra...