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by Ervin R. Fox , J Hunter Young , Yali Li , Albert W. Dreisbach , Brendan J. Keating , Solomon K. Musani , Kiang Liu , Alanna C. Morrison , Santhi Ganesh , Abdullah Kutlar , Vasan S. Ramach , Josef F. Polak , Richard R. Fabsitz , Daniel L. Dries , Deborah N. Farlow , Susan Redline , Adebowale Adeyemo , Joel N. Hirschorn , Yan V , Sun Sharon B. Wyatt , Raymond R. Townsend , Ayo P. Doumatey , Bamidele O. Tayo , Thomas H. Mosley , Helen N. Lyon , Sun J. Kang , Charles N. Rotimi , Richard S. Cooper , Herman A. Taylor , Mark J. Caulfield , Georg B. Ehret , Toby Johnson , Aravinda Chakravarti , Xiaofeng Zhu , Daniel Levy

Citations

1909	PLINK: a tool set for whole-genome association and population-based linkage analyses - Purcell, Neale, et al. (Show Context) Citation Context ...ssusing the Illumina iSelect HumanCVD bead array.(28)sWe excluded individuals younger thans18 years of age.sGenotyping and quality controlsQuality control of genotyping data was performedsusingsPLINK.=-=(29)-=-sQuality controlsefforts were conducted at two levels: exclusion of individuals and exclusion of SNPs. Samplesswith genotyping success rate <95% were removed. An inbreeding coefficient was calculateds...
249	Heart disease and stroke statistics-2007 update: A report from the american heart association statistics committee and stroke statistics subcommittee - Rosamond, Flegal - 2007 (Show Context) Citation Context ...issalso greater among African Americans than European Americans.(1,3) Furthermore, in 2004 thesdeath rate from hypertension was three times greater in African Americans compared tosEuropean Americans.=-=(4,5)-=-sA portion of the excess burden of hypertension among African Americans may be due tosgenetic susceptibility. Admixture mapping analysis of hypertension suggested that Africansancestry is associated w...
86	Methods for high-density admixture mapping of disease genes. - Patterson - 2004 (Show Context) Citation Context ...rom different geographical regions because the LD is dependent on thesadmixture proportion. It has been reported that the admixture proportion rate is different acrosssthe African-American population.=-=(26,27)-=- Thus, replication analysis can be challenging insAfrican-American populations.sThese limitations are leveraged against the advantage of using large community-basedscohorts of African Americans for th...
54	Newly identified loci that influence lipid concentrations and risk of coronary artery disease - Willer, Sanna, et al. - 2008 (Show Context) Citation Context ...l (deoxy)adenine nucleotides and adenosine 3’, 5’ -diphosphate.(19)sSNPs insthis region were associated with LDL cholesterol and triglyceride levels in a whole genomesanalysis of European populations.=-=(20)-=-sTwo tightly linked SNPs, rs4930130 and rs1791926 (r2=1.0) on chromosome 11, weresassociated with DBP with p < 1×10-5.sThey are in proximity to KCNQ1, which encodes a proteinsfor a voltage-gated potas...
48	A high-density admixture map for disease gene discovery in african americans. - Smith - 2004 (Show Context) Citation Context ...rom different geographical regions because the LD is dependent on thesadmixture proportion. It has been reported that the admixture proportion rate is different acrosssthe African-American population.=-=(26,27)-=- Thus, replication analysis can be challenging insAfrican-American populations.sThese limitations are leveraged against the advantage of using large community-basedscohorts of African Americans for th...
40	A genome-wide association study of hypertension and blood pressure in - Adeyemo, Gerry, et al. - 2009 (Show Context) Citation Context ...tify anysSNPs reaching genome-wide significance (p <5×10-8) with hypertension, although six weresassociated with blood pressure SBP in a secondary analysis in a subset of 508 normotensivesindividuals.=-=(7)-=- The present study represents the largest GWAS for blood pressure in AfricansAmericans to date.sWe also attempted replication of our top findings in individuals of Africansat Pennsylvania State U nive...
39	Admixture mapping for hypertension loci with genome-scan markers. - Zhu, Luke, et al. - 2005 (Show Context) Citation Context ... excess burden of hypertension among African Americans may be due tosgenetic susceptibility. Admixture mapping analysis of hypertension suggested that Africansancestry is associated with hypertension.=-=(6)-=-sTwo recent genome-wide association studiess(GWAS) of blood pressure, each involving about 30,000 participants of European descent, havesidentified common genetic variants at 13 loci that are associat...
39	Genome-wide association study identifies eight loci associated with blood pressure. - Newton-Cheh - 2009 (Show Context) Citation Context ...ns of EuropeansancestrysTwo large scale GWAS in European populations have been published and 13sindependent loci have been shown to be associated with blood pressure at a genome-widessignificant level=-=(10,11)-=-.sWe then performed one-sided test to examine if the associationsevidence for these published loci can be replicated in the CARe datasets. The one-sided testsensures the effect directions are the same...
38	Genome-wide association study of blood pressure and hypertension. Nat Genet. - Levy, GB, et al. - 2009 (Show Context) Citation Context ...ns of EuropeansancestrysTwo large scale GWAS in European populations have been published and 13sindependent loci have been shown to be associated with blood pressure at a genome-widessignificant level=-=(10,11)-=-.sWe then performed one-sided test to examine if the associationsevidence for these published loci can be replicated in the CARe datasets. The one-sided testsensures the effect directions are the same...
38	GWAF: an R package for genome-wide association analyses with family data. Bioinformatics. - MH, Yang - 2010 (Show Context) Citation Context ...s withsSBP and DBP was tested by linear regression with additive genetic model using PLINK; forsCFS, association was tested using a linear mixed effect (LME) model that accounted for familysstructure.=-=(32)-=-sMeta-analysis of results was carried out using the inverse-variance weighting method insMETAL (http://www.sph.umich.edu/csg/abecasis/metal/). Genomic control was carried out onscohort-specific test s...
19	Trends in hypertension prevalence, awareness, treatment, and control rates - Cutler, Sorlie, et al. - 2008 (Show Context) Citation Context ... from the National Health and Nutrition ExaminationsSurvey (NHANES) collected between 1999 and 2004, the prevalence of hypertension in AfricansAmericans was 40%, compared to 27% in European Americans.=-=(1,2)-=- The risk of sufferingshypertensive end-organ damage including end-stage renal disease, heart failure, and stroke issalso greater among African Americans than European Americans.(1,3) Furthermore, in ...
17	Concept, design and implementation of a cardiovascular genecentric 50 k snp array for large-scale genomic association studies. - Keating, Tischfield, et al. - 2008 (Show Context) Citation Context ...ray and blood pressure data for association analysis. Six cohortss(ARIC, CARDIA, CFS, CHS, JHS, MESA) had candidate gene genotyping in African Americanssusing the Illumina iSelect HumanCVD bead array.=-=(28)-=-sWe excluded individuals younger thans18 years of age.sGenotyping and quality controlsQuality control of genotyping data was performedsusingsPLINK.(29)sQuality controlsefforts were conducted at two le...
14	Mice lacking P2Y2 receptors have salt-resistant hypertension and facilitated renal Na+ and water reabsorption. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21, 3717-3726 VITA Nabila Boukelmoune was - Rieg, Bundey, et al. - 2007 (Show Context) Citation Context ...,23) Geneticsdefects in this channel in humans have been associated with hypertension in Liddle’s syndrome.sP2Y2 (a homologue of P2RY2) knock-out mice manifest a salt resistant hypertensivesphenotype.=-=(24)-=-sA recent case control association study by Wang et al. showed an associationsof P2RY2 with hypertension in Japanese men.(25)sAssociation evidence of SNPs with blood pressure in CARDIAsat Pennsylvania...
14	Adjusting for treatment effects in studies of quantitative traits: Antihypertensive therapy and systolic blood pressure - Tobin, Sheehan, et al. - 2005 (Show Context) Citation Context ...e average of the second and third bloodspressure measurements was used for these analyses.sFor individuals taking antihypertensivesmedication, we added 10 mm Hg and 5 mm Hg to the measured SBP and DBP=-=(31)-=-,sat Pennsylvania State U niversity on Septem ber 16, 2016 http://hm g.oxfordjournals.org/ D ow nloaded from 15srespectively, to account for treatment effect.sContinuous DBP and SBP were adjusted for ...
12	African American women and men at high and low risk for hypertension: A signal detection analysis of NHANES III - Collins, Winkleby - 1988 (Show Context) Citation Context ...ropean Americans.(1,2) The risk of sufferingshypertensive end-organ damage including end-stage renal disease, heart failure, and stroke issalso greater among African Americans than European Americans.=-=(1,3)-=- Furthermore, in 2004 thesdeath rate from hypertension was three times greater in African Americans compared tosEuropean Americans.(4,5)sA portion of the excess burden of hypertension among African Am...
12	Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs - Adkins, Aberg, et al. - 2010 (Show Context) Citation Context ...d in Usherssyndrome characterized by hearing loss and retinitis pigmentosa. SNPs in GPR98 have beensassociated with markers of hyperglycemia in patients taking the antipsychotic medicationsolanzapine.=-=(12)-=-sArrestin C is a peroxisome proliferator-activated receptor gamma (PPARG)sligand and PPARG activator.sPPARs are a family of nuclear receptors that are activated bysnutrient molecules and their derivat...
11	A unified association analysis approach for family and unrelated samples correcting for stratification - Zhu, Li, et al. - 2008 (Show Context) Citation Context ...al plots of association for the genome-wide significant locisare presented in Figure 1.sPooled genotype data analysis was conducted for the five cohorts with Affymetrix 6.0sgenotyping data using FamCC=-=(8)-=- , on genotyped SNPs only. In general, the results were highlysconsistent with those from the meta-analysis.sAssociation of SNPs on the IBC chip with blood pressuresMeta-analysis of CARe cohorts with ...
11	Genome-wide association of anthropometric traits in African- and African-derived - Kang, Chiang, et al. - 2010 (Show Context) Citation Context ...ed in Supplementary Table 4.sLookup of published SNPs from previous studies of people with African ancestrysWe examined whether published SNPs from GWAS of blood pressure in people ofsAfrican ancestry=-=(9)-=- could be replicated in our sample (Supplementary Table 2A).sNone of thespreviously reported loci for SBP or DBP replicated in our study.sLookups of published SNPs from previous studies including popu...
11	Luminal P2Y2 receptor-mediated inhibition of Na+ absorption in isolated perfused mouse CCD. - Lehrmann, Thomas, et al. - 2002 (Show Context) Citation Context ...erative stimuli.sThere issevidence that the purinergic system may affect the activity of epithelial sodium channel (ENaC)sin the renal collecting duct, which is responsible for reabsorption of sodium.=-=(22,23)-=- Geneticsdefects in this channel in humans have been associated with hypertension in Liddle’s syndrome.sP2Y2 (a homologue of P2RY2) knock-out mice manifest a salt resistant hypertensivesphenotype.(24)...
9	Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature - Duan, Usher, et al. - 2008 (Show Context) Citation Context ...utrient molecules and their derivatives.(13) PPARG activators may play a role in hypertensionsand atherosclerosis through modification of inflammation and the innate immunity system insvascular cells.=-=(13,14)-=-sAnother locus that reached genome wide significance for SBP in CARe AA cohorts is onschromosome 21,where a region was previously reported in admixture mapping analysis.(15)sThe top SNP at this locus,...
9	Admixture mapping provides evidence of association of the VNN1 gene with hypertension. PLoS - Zhu, Cooper - 2007 (Show Context) Citation Context ...ystem insvascular cells.(13,14)sAnother locus that reached genome wide significance for SBP in CARe AA cohorts is onschromosome 21,where a region was previously reported in admixture mapping analysis.=-=(15)-=-sThe top SNP at this locus, rs2258119 (P=4.7×10-8), is in tight LD with missense variantsrs2824495 in C21orf91 (pairwise r2=1.0).sThe minor allele frequencies of this SNP in HapMapsCEU and YRI samples...
8	Programmed hypertension: kidney, brain or both? Trends Endocrinol - Dodic, Moritz, et al. - 2002 (Show Context) Citation Context ... through nucleocytoplasmic shuttling.(17)sThere is a potential linksproposed between early-onset glucocorticoid exposure and hypertension through changes insgene expression and function in the kidney.=-=(18)-=-sOf note, another importin beta protein (IPO7)swas identified by Adeyemo et al in a genome wide association analysis of a normotensivessubset of African Americans.(7)sTop SNPs from the meta-analysis o...
6	PPARs: the vasculature, inflammation and hypertension - Duan, Usher, et al. - 2009 (Show Context) Citation Context ...stin C is a peroxisome proliferator-activated receptor gamma (PPARG)sligand and PPARG activator.sPPARs are a family of nuclear receptors that are activated bysnutrient molecules and their derivatives.=-=(13)-=- PPARG activators may play a role in hypertensionsand atherosclerosis through modification of inflammation and the innate immunity system insvascular cells.(13,14)sAnother locus that reached genome wi...
6	Importin 13 regulates nuclear import of the glucocorticoid receptor in airway epithelial cells - Tao, Lan, et al. - 2006 (Show Context) Citation Context ... that modifies nuclearsat Pennsylvania State U niversity on Septem ber 16, 2016 http://hm g.oxfordjournals.org/ D ow nloaded from 9savailability of glucocorticoids through nucleocytoplasmic shuttling.=-=(17)-=-sThere is a potential linksproposed between early-onset glucocorticoid exposure and hypertension through changes insgene expression and function in the kidney.(18)sOf note, another importin beta prote...
6	Long QT syndrome-associated mutations in the voltage sensor of I(Ks) channels. - Henrion, Strutz-Seebohm, et al. - 2009 (Show Context) Citation Context ...tion phase of the cardiac actionspotential. The gene productsis associated with hereditary long QT syndrome, Romano-Wardssyndrome, Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation.=-=(21)-=- Another signalsof interest was found for rs1791926, near P2RY2 (purinergic receptor P2Y, G coupled 2) onschromosome 11q13.5-q14.1 that mediates vasoactive and proliferative stimuli.sThere issevidence...
6	Candidate Gene Association Resource (CARe): Design, Methods, and Proof of Concept - Musunuru, Lettre, et al. - 2010 (Show Context) Citation Context ...ata genotypes on the ~8500 individuals of Africansancestry it was possible to assess the quality of the imputation process.sThe observedsconcordance was 95.6%, which is comparable to previous studies.=-=(30)-=- Imputation wassperformed for the Affymetrix 6.0 data only.sPhenotype modelingsSystolic (SBP) and diastolic (DBP) blood pressures were modeled at the firstsexamination for ARIC, CHS, MESA and JHS, and...
5	CAR-diology--a virus receptor in the healthy and diseased - Fischer, Poller, et al. - 2009 (Show Context) Citation Context ...ceptors), which encodes a tight junctionsprotein of the intercalated disks between cardiomyocytes. This protein is an entry point for virussuptake in myocarditis and is involved in cardiac remodeling.=-=(16)-=-sA SNP of interest, rs1990151son chromosome 1, showed suggestive association with SBP (p=7.4×10-7).sThis is an intronicsSNP in importin beta (IPO13).sImportin beta is a nuclear transport protein that ...
5	A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3′,5′-diphosphate in human mitochondria. - Fiermonte, Paradies, et al. - 2009 (Show Context) Citation Context ...otein that transports cofactor coenzyme As(CoA) and adenosine 3’, 5’ -diphosphate into the mitochondria in exchange forsintramitochondrial (deoxy)adenine nucleotides and adenosine 3’, 5’ -diphosphate.=-=(19)-=-sSNPs insthis region were associated with LDL cholesterol and triglyceride levels in a whole genomesanalysis of European populations.(20)sTwo tightly linked SNPs, rs4930130 and rs1791926 (r2=1.0) on c...
5	Lessons from mouse mutants of epithelial sodium channel and its regulatory proteins - Hummler, Vallon - 2005 (Show Context) Citation Context ...erative stimuli.sThere issevidence that the purinergic system may affect the activity of epithelial sodium channel (ENaC)sin the renal collecting duct, which is responsible for reabsorption of sodium.=-=(22,23)-=- Geneticsdefects in this channel in humans have been associated with hypertension in Liddle’s syndrome.sP2Y2 (a homologue of P2RY2) knock-out mice manifest a salt resistant hypertensivesphenotype.(24)...
4	Racial disparities in hypertension prevalence - Hertz, Unger, et al. - 2005 (Show Context) Citation Context ... from the National Health and Nutrition ExaminationsSurvey (NHANES) collected between 1999 and 2004, the prevalence of hypertension in AfricansAmericans was 40%, compared to 27% in European Americans.=-=(1,2)-=- The risk of sufferingshypertensive end-organ damage including end-stage renal disease, heart failure, and stroke issalso greater among African Americans than European Americans.(1,3) Furthermore, in ...