requiring direct access to a specified gene's DNA. For inherited diseases mapped in this way, linked DNA marker loci can be used predictively for genetic counseling.

This report on genetic counselling and its bioethical implications, is a natural extension of the 1994 Reports on genetic screening and testing, and on gene therapy(1, 2), because it addresses the impact that these fields of science have on the individual person (born or to-be-born) and sometimes

but no family history of NF-1. Sixty-nine of the families were identified through a population based study in south east Wales and the frequency of complications in 135 affected subjects from these families has been used to develop figures for genetic counselling. For these purposes, the complications of NF-1

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Telling the Truth about Turner Syndrome: Disclosure of a diagnosis and infertility to a romantic partner

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pathology in our patient was characteristic of the classical variety. The ideal mode of management is still uncertain. The first line of management in the cases reported, is surgery-either total or partial excision of the tumor mass. Twenty eight of the 35 cases in Rubinstein's series underwent surgery of whom 22 patients survived post operation. Nine of these patients had recurrences in a period ranging from 6 months to 7 years. All 11 cases in Berger's series were operated and were also subjected to post-operative radiotherapy to prevent recur-rences. Four patients showed a recurrence. Recurrences are reported to be common in those patients with solid tumors and those undergoing subtotal resection. Recurrences were managed by surgery or a combination of multiple chemotherapy with radio-therapy. In summary, primary cerebral neuro-blastoma is a rare type of neuroectodcural

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