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Results 31 - 40
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1,321
Therapeutic Hypothermia Activates the Endothelin and Nitric Oxide Systems after Cardiac Arrest in a Pig Model
"... Post-cardiac arrest myocardial dysfunction is a major cause of mortality in patients receiving successful cardiopulmonary resuscitation (CPR). Mild therapeutic hypothermia (MTH) is the recommended treatment after resuscitation from cardiac arrest (CA) and is known to exert neuroprotective effects an ..."
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Post-cardiac arrest myocardial dysfunction is a major cause of mortality in patients receiving successful cardiopulmonary resuscitation (CPR). Mild therapeutic hypothermia (MTH) is the recommended treatment after resuscitation from cardiac arrest (CA) and is known to exert neuroprotective effects
Therapeutic Hypothermia after Resuscitated Cardiac Arrest
"... The purpose of this protocol is to improve the neurologic outcomes of patients who have experienced cardiac arrest and have been successfully resuscitated. Approximately 5-30 % of patients resuscitated from cardiac arrest survive to leave the hospital, and the majority of these patients have suffere ..."
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of mild hypothermia in patients following cardiac arrest may achieve this goal. In 2002, two randomized controlled studies demonstrated statistically significant improvements in the neurologic outcomes of patients treated with mild induced hypothermia vs. placebo following cardiac arrest. The Bernard, S
Perinatal Events and Early MRI in Therapeutic Hypothermia
"... Objective—To compare the association between perinatal events and the pattern and extent of brain injury on early MRI in newborns with and without therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE). Study design—We performed a cohort study of 35 treated and 25 non-treated neonates who ..."
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Objective—To compare the association between perinatal events and the pattern and extent of brain injury on early MRI in newborns with and without therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE). Study design—We performed a cohort study of 35 treated and 25 non-treated neonates
COMMENTARY Out-of-hospital CPR: better outcome for our patients
"... Out-of-hospital cardiac arrest is a leading cause of death in developed countries and early resuscitation attempts are crucial to improve survival rates and neurological outcome. Gräsner and colleagues performed an intriguing analysis on the combined approach of mild therapeutic hypothermia (MTH) an ..."
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Out-of-hospital cardiac arrest is a leading cause of death in developed countries and early resuscitation attempts are crucial to improve survival rates and neurological outcome. Gräsner and colleagues performed an intriguing analysis on the combined approach of mild therapeutic hypothermia (MTH
B: Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling. PLoS One 2009
"... Background: Mild therapeutic hypothermia following cardiac arrest is neuroprotective, but its effect on myocardial dysfunction that is a critical issue following resuscitation is not clear. This study sought to examine whether hypothermia and the combination of hypothermia and pharmacological postco ..."
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Cited by 9 (3 self)
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Background: Mild therapeutic hypothermia following cardiac arrest is neuroprotective, but its effect on myocardial dysfunction that is a critical issue following resuscitation is not clear. This study sought to examine whether hypothermia and the combination of hypothermia and pharmacological
Therapeutic hypothermia for acute stroke
- Int J Stroke
"... The online version of this article, along with updated information and services, is located on the ..."
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Cited by 10 (0 self)
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The online version of this article, along with updated information and services, is located on the
MEETING ABSTRACT Open Access Let’s get started with targeted temperature
"... Cardiac arrest (CA) remains a major cause of death and severe disability worldwide. The ischemic process that follows the cessation of cerebral perfusion and oxygena-tion, which is further worsened by the reperfusion injury occurring after the return of spontaneous circulation, can lead to severe hy ..."
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hypoxic brain damage, resulting in a high rate of poor neurological recovery among CA survivors. The use of mild therapeutic hypothermia, or targeted temperature management (TTM) as recently suggested [1], has been recommended in CA patients since the pub-lication of two randomized clinical trials in 2002
Enhanced Dispersion of Repolarization Explains Increased Arrhythmogenesis in Severe Versus Therapeutic Hypothermia
"... Background—Hypothermia is proarrhythmic, and, as the use of therapeutic hypothermia (TH) increases, it is critically important to understand the electrophysiological effects of hypothermia on cardiac myocytes and arrhythmia substrates. We tested the hypothesis that hypothermia-enhanced transmural di ..."
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Background—Hypothermia is proarrhythmic, and, as the use of therapeutic hypothermia (TH) increases, it is critically important to understand the electrophysiological effects of hypothermia on cardiac myocytes and arrhythmia substrates. We tested the hypothesis that hypothermia-enhanced transmural
USE OF THERAPEUTIC HYPOTHERMIA FOR ISCHEMIC AND
"... My lab uses animal models of cerebral ischemia and intracerebral hemorrhage (ICH) to study mechanisms of injury, and to develop and test therapies to limit brain injury (neuroprotection) and/or to promote functional recovery (rehabilitation). In this talk I will discuss my 20+ years of research with ..."
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with therapeutic hypothermia ± an intentional reduction in body or brain temperature by a few degrees often for periods of 12 hours or more (e.g., 24 hours at 32 °C). In rodent models of global and focal ischemia, we find that cooling is a superior neuroprotectant that results in lasting reductions in brain injury
The Small Chill: mild hypothermia for cardioprotection?
, 2011
"... small chill: mild hypothermia for cardioprotection?. Cardiovasc Res, 2010, 88 (3), pp.406-14. ..."
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small chill: mild hypothermia for cardioprotection?. Cardiovasc Res, 2010, 88 (3), pp.406-14.
Results 31 - 40
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1,321
