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Parental antagonism, relatedness asymmetries, and genomic imprinting

by David Haig - Proc R Soc Lond B , 1997
"... The theory of inclusive ¢tness can be modi¢ed to consider separate coe¤cients of relatedness for an indivi-dual's maternal and paternal alleles. A gene is said to have parentally antagonistic e¡ects if it has an inclusive ¢tness bene¢t when maternally derived, but an inclusive ¢tness cost when ..."
Abstract - Cited by 42 (11 self) - Add to MetaCart
paternally derived (or vice versa). Parental antagonism favours the evolution of alleles that are expressed only when maternally derived or only when paternally derived (genomic imprinting). 1.

interact to shape family life

by Joël Meunier, Mathias Kölliker, Joël Meunier, Mathias Kölliker , 2012
"... Parental antagonism and parent−offspring co-adaptation ..."
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Parental antagonism and parent−offspring co-adaptation

Salt-resistant alpha-helical cationic antimicrobial peptides

by Carol Friedrich, Monisha G. Scott, Nedra Karunaratne, Hong Yan, Robert E. W. Hancock , 1999
"... Analogues based on the insect cecropin–bee melittin hybrid peptide (CEME) were studied and analyzed for activity and salt resistance. The new variants were designed to have an increase in amphipathic a-helical con-tent (CP29 and CP26) and in overall positive charge (CP26). The a-helicity of these pe ..."
Abstract - Cited by 23 (2 self) - Add to MetaCart
-helicity of these peptides was demonstrated by circular dichroism spectroscopy in the presence of liposomes. CP29 was shown to have activity against gram-negative bacteria that was similar to or better than those of the parent peptides, and CP26 had similar activity. CP29 had cytoplasmic membrane permeabilization activity

Specialists and generalists: The sexual ecology of the genome

by David Haig, Manus M. Patten - In , 2014
"... Sexual antagonism occurs when an allele is beneficial in one sex but costly in the other. Parental antagonism occurs when an allele is beneficial when inherited from one sex but costly when inherited from the other because of fitness interactions among kin. Sexual and parental antagonisms together d ..."
Abstract - Cited by 2 (0 self) - Add to MetaCart
Sexual antagonism occurs when an allele is beneficial in one sex but costly in the other. Parental antagonism occurs when an allele is beneficial when inherited from one sex but costly when inherited from the other because of fitness interactions among kin. Sexual and parental antagonisms together

Genome-wide association analysis identifies 13 new risk loci for schizophrenia.

by Stephan Ripke - Nat. Genet. , 2013
"... Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,00 cases and 6,243 controls) followed by meta-analysis with ..."
Abstract - Cited by 32 (1 self) - Add to MetaCart
-analysis with previous schizophrenia GWAS (8,832 cases and 2,067 controls) and finally by replication of SNPs in 68 genomic regions in independent samples (7,43 cases, 9,762 controls and 58 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 3 of these are new, and was previously

Trajectories of Children's Social Interactions With Their Infant Sibling in the First Year: A Multidimensional Approach

by Wonjung Oh , Brenda L Volling , Richard Gonzalez
"... Individual differences in longitudinal trajectories of children's social behaviors toward their infant sibling were examined simultaneously across multiple social dimensions: Positive engagement (moving toward), antagonism (moving against), and avoidance (moving away). Three distinct social pa ..."
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, and became increasingly avoidant over time. A path model, guided by a Process ϫ Person ϫ Context ϫ Time model, revealed that low parental self-efficacy heightened by parenting stress and children's dysregulated temperament was directly related to the escalating-antagonism pattern. Punitive parenting

Ethnic Differences in the Impact of Parental Myopia: Findings from a Population-Based Study of 12-Year-Old

by Australian Children
"... PURPOSE. To examine the influences of ethnicity, parental my-opia, and near work on spherical equivalent refraction (SER) and axial length (AL) in a population-based sample of 12-year-old Australian children. METHODS. Year-7 children in the Sydney Myopia Study (n 2353, 75.3 % response) underwent an ..."
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ethnicity. In the nonmyopic children, there was no association between parental myopia and AL. CONCLUSIONS. In this sample, parental myopia was associated with more myopic SER and longer AL, with significant ethnic interactions. (Invest Ophthalmol Vis Sci. 2007;48:2520–2528)

DOI 10.1007/s12124-010-9148-1 COMMENTARY Kowakare: A New Perspective on the Development

by Of Early Mother–offspring Relationship, Koichi Negayama, K. Negayama , 2010
"... # The Author(s) 2010. This article is published with open access at Springerlink.com Abstract The mother–offspring relationship has components of both positivity and negativity. Kowakare is a new concept introduced to explain an adaptive function of the negativity in the early mother-offspring relat ..."
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-offspring relationship. Kowakare is the psychosomatic development of the relationship as the process of accumulation in the otherness of offspring. Early human Kowakare has two frameworks, biological interbody antagonism and socio-cultural allomothering compensating the antagonism. Some features of feeding

Effect of Culture Media on the Antifungal Activity of

by Amphotericin B Methyl Ester, Paul D. Hoeprich, Immunologic Diseases
"... The capacity of four culture media to obfuscate the antifungal activity of miconazole and amphotericin B methyl ester was evaluated qualitatively by examination of five isolates each of Candida albicans, Candida tropicalis, Candida parapsilosis, Toru-lopsis glabrata, and Cryptococcus neojormans, and ..."
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, and quantitatively by determination of the absolute minimal inhibitory concentrations for a strain of C. albicans. Mi-conazole, like the predecessor imidazo.e (clotrimazole), was antagonized by two complex, undefined media (Sabouraud's glucose and brain-heart infusion agars) but not by either of two synthetic

Kinetics and significance of the activity of the Sabath and Abrahams' /Mactamase of Pseudomonas aeruginosa against cefotaxime and cefsulodin

by D. M. Livermore, Abrahams (sa - Journal of Antimicrobial Chemotherapy , 1983
"... enzyme, as inducible /Mactamase. Hydrolysis of cefotaxime by this enzyme, although slow in terms of V^ ^ was efficient when the parameter V^^/Km (physiological efficiency (Pollock, 1965)) was considered. Hydrolysis of cefsulo-din was not detectable in assays used and enzyme binding (Ki) was poor, en ..."
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") or constitutive (SAP3") mutants where SA expression was independent of cephaloridine concentration. This indicated the antagonism was SA dependent. Cefotaxime plate MICs against parent SAI+ and uninducible SAI ~ organisms were similar indicating cefotaxime did not induce SA enzyme in these tests. Cefotaxime
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