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Functional heterogeneity within Broca's area during verbal (2002)
| Citations: | 25 - 2 self |
BibTeX
@MISC{Chein02functionalheterogeneity,
author = {Working Memory Chein and J. M. Chein A and K. Fissell C and S. Jacobs D and J. A. Fiez A},
title = {Functional heterogeneity within Broca's area during verbal},
year = {2002}
}
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Abstract
In previous fMRI research, we found that two subregions of the left inferior frontal cortex showed distinct patterns of activity during a verbal working memory task. Specifically, a more dorsal region tracked with performance, while a more ventral region was sensitive to lexical status. To test the veracity of this finding, we developed a new method for meta-analysis of neuroimaging results. In this method, Gaussian probability distributions are formed around stereotaxic coordinates obtained from published neuroimaging studies. These probability distributions are then combined to identify regions of convergence across studies. When this method was applied to prior studies of working memory, the results largely paralleled those from earlier reviews of the literature on working memory, but also confirmed our empirical findings showing distinct foci within Broca's area. Further application of this meta-analytic technique substantiated the dissociation in these regions for performance and sublexical processing. These results help to validate a novel approach for meta-analysis of neuroimaging findings that avoids many of the subjective assumptions involved in alternative approaches.
Keyphrases
functional heterogeneity ventral region prior study subjective assumption verbal working memory task distinct focus new method left inferior frontal cortex stereotaxic coordinate lexical status distinct pattern previous fmri research probability distribution alternative approach novel approach dorsal region meta-analytic technique empirical finding gaussian probability distribution sublexical processing
