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Centrosome defects and genetic instability in malignant tumors (1998)
| Venue: | Woda B, Quesenberry P, and Doxsey SJ |
| Citations: | 91 - 6 self |
BibTeX
@INPROCEEDINGS{Pihan98centrosomedefects,
author = {German A. Pihan and Aruna Purohit and Janice Wallace and Et Al and Contact The Aacr Publications and German A. Pihan and Aruna Purohit and Janice Wallace and Hans Knecht and Bruce Woda and Peter Quesenberry and Stephen J. Doxsey},
title = {Centrosome defects and genetic instability in malignant tumors},
booktitle = {Woda B, Quesenberry P, and Doxsey SJ},
year = {1998},
pages = {3974--3985}
}
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Abstract
Genetic instability is a common feature of many human cancers. This condition is frequently characterized by an abnormal number of chromo somes, although little is known about the mechanism that generates this altered genetic state. One possibility is that chromosomes are missegregated during mitosis due to the assembly of dysfunctional mitotic spindles. Because ccntrosomes are involved in spindle assembly, they could con tribute to chromosome missegregation through the organization of aber rant spindles. As an initial test of this idea, we examined malignant tumors for centrosome abnormalities using antibodies to the centrosome protein l>rritrndin. We found that centrosomes in nearly all tumors and tumorderived cell lines were atypical in shape, size, and composition and were often present in multiple copies. In addition, virtually all pericentrinstaining structures in tumor cells nucleated microtubules, and they par ticipated in formation of disorganized mitotic spindles, upon which chro
