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doi:10.1093/mutage/geu076 Original Article Original Manuscript Genetic variants in lncRNA HOTAIR are
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@MISC{Hua_doi:10.1093/mutage/geu076original,
author = {Qiuhan Hua and Haiyan Chu and Na Tong and Jinfei Chen and Meilin Wang},
title = {doi:10.1093/mutage/geu076 Original Article Original Manuscript Genetic variants in lncRNA HOTAIR are},
year = {}
}
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Abstract
†These authors contributed equally to this work. ‡These authors jointly directed this work. Long non-coding RNA HOX transcript antisenseRNA (HOTAIR) has been widely identified to participate in tumour pathogenesis, acting as a promoter in colorectal cancer carcinogenesis. However, the association between genetic variants in HOTAIR and cancer risk has not yet been reported. In the present study, we performed a two-stage case–control study to investigate the association between HOTAIR tagSNPs and the risk of colorectal cancer. We found that individuals with rs7958904 CC genotype had a significantly decreased risk of colorectal cancer in both Stage 1 and 2, compared with those carrying
