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logy of Medisch Spectrum Twente, Enschede, the Netherlands. Publication of this thesis was financially supported by:

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by Han Otte , Stichting Inwendig , Geneeskundig Onderzoek Enschede , Roche Nederland Bv , Novartis Pharma Bv , Astra Zeneca Bv , Ge Healthcare , Stichting Zorgsaam Zeeuws-vlaanderen , Rector Magnificus , Johannes Adrianus Otte