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Assembly of cell regulatory systems through protein interaction domains (2003)
| Venue: | Science |
| Citations: | 277 - 8 self |
BibTeX
@ARTICLE{Pawson03assemblyof,
author = {Tony Pawson and Piers Nash},
title = {Assembly of cell regulatory systems through protein interaction domains},
journal = {Science},
year = {2003},
pages = {445--452}
}
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Abstract
The sequencing of complete genomes provides a list that includes the proteins responsible for cellular regulation. However, this does not immediately reveal what these proteins do, nor how they are assembled into the molecular machines and functional networks that control cellular behavior. The regulation of many different cellular processes requires the use of protein interaction domains to direct the association of polypeptides with one another and with phospholipids, small molecules, or nucleic acids. The modular nature of these domains, and the flexibility of their binding properties, have likely facilitated the evolution of cellular pathways. Conversely, aberrant interactions can induce abnormal cellular behavior and disease. The fundamental properties of protein interaction domains are discussed in this review and in detailed reviews on individual domains at Science’s STKE at
Keyphrases
protein interaction domain cell regulatory system many different cellular process modular nature abnormal cellular behavior molecular machine small molecule protein interaction binding property complete genome individual domain fundamental property cellular behavior cellular regulation aberrant interaction detailed review cellular pathway nucleic acid functional network
