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Review The diagnosis and management of pre-invasive breast disease Genetic alterations in pre-invasive lesions (2003)
BibTeX
@MISC{Reis-filho03reviewthe,
author = {Jorge S Reis-filho and Sunil R Lakhani},
title = {Review The diagnosis and management of pre-invasive breast disease Genetic alterations in pre-invasive lesions},
year = {2003}
}
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Abstract
The development of modern molecular genetic techniques has allowed breast cancer researchers to clarify the multistep model of breast carcinogenesis. Laser capture microdissection coupled with comparative genomic hybridisation and/or loss-of-heterozygosity methods have confirmed that many pre-invasive lesions of the breast harbour chromosomal abnormalities at loci known to be altered in invasive breast carcinomas. Current data do not provide strong evidence for ductal hyperplasia of usual type as a precursor lesion, although some are monoclonal proliferations; however, atypical hyperplasia and in situ carcinoma appear to be nonobligate precursors. We review current knowledge and the contribution of molecular genetics in the understanding of breast cancer precursors and preinvasive lesions.
Keyphrases
pre-invasive lesion pre-invasive breast disease genetic alteration multistep model laser capture microdissection current data strong evidence invasive breast carcinoma monoclonal proliferation usual type ductal hyperplasia atypical hyperplasia cancer researcher comparative genomic hybridisation molecular genetics precursor lesion situ carcinoma breast carcinogenesis many pre-invasive lesion breast harbour chromosomal abnormality loss-of-heterozygosity method current knowledge breast cancer precursor modern molecular genetic technique preinvasive lesion nonobligate precursor
