DMCA
O.: Refining dynamics of gene regulatory networks in a stochastic π-calculus framework (2011)
| Venue: | In: Transactions on Computational Systems Biology XIII |
| Citations: | 12 - 9 self |
BibTeX
@INPROCEEDINGS{Paulevé11o.:refining,
author = {Loïc Paulevé and Morgan Magnin and Olivier Roux},
title = {O.: Refining dynamics of gene regulatory networks in a stochastic π-calculus framework},
booktitle = {In: Transactions on Computational Systems Biology XIII},
year = {2011},
pages = {171--191},
publisher = {Springer}
}
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Abstract
Abstract. In this paper, we introduce a framework allowing to model and analyse efficiently Gene Regulatory Networks in their temporal and stochastic aspects. The analysis of stable states and inference of René Thomas ’ discrete parameters derives from this logical formalism. We offer a compositional approach which comes with a natural translation to the Stochastic π-Calculus. The method we propose consists in successive refinements of generalized dynamics of Gene Regulatory Networks. We apply this method to the control of the differentiation in a Gene Regulatory Network generalizing metazoan segmentation processes. 1
