DMCA
Hydrogen-Peroxide-Enhanced Nonthermal Plasma Effluent for Biomedical Applications
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BibTeX
@MISC{Gołkowski_hydrogen-peroxide-enhancednonthermal,
author = {Marek Gołkowski and Czesław Gołkowski and Jori Leszczynski and S. Reed Plimpton and Piotr Masłowski and Ra Foltynowicz and Jun Ye and Bruce Mccollister},
title = {Hydrogen-Peroxide-Enhanced Nonthermal Plasma Effluent for Biomedical Applications},
year = {}
}
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Abstract
Abstract—A novel nonthermal plasma dielectric-barrier dis-charge (DBD) system for decontamination, sterilization, and med-ical applications has been developed. The discharge is physically removed from the disinfection zone, and plasma-induced free radicals are delivered through an air stream. The physical distance between the discharge and the treatment surface can be up to 3 m, making the technology robust and flexible for applications in the medical clinic. The bactericidal properties of the free-radical effluent are enhanced by hydrogen peroxide additives. We report a 6-log reduction in Staphylococcus aureus and Pseudomonas aeruginosa bacteria strains in under 1 min of exposure in vitro and inactivation of Bacillus atrophaes spores and Escherichia coli biofilms. The concentration of hydrogen peroxide additives is seen to be a key variable in inactivation efficacy, suggesting that active species in our experiment may be different than in other DBD con-figurations. Precise chemical concentration measurements using direct frequency comb spectroscopy show presence of ozone (O3), hydrogen peroxide (H2O2), nitrous oxide (N2O), and nitrogen dioxide (NO2). In vivo multiple exposures of mouse skin to the plasma effluent do not yield any adverse effects. Index Terms—Bacteria, biomedical, decontamination, fre-quency comb spectroscopy, plasma medicine, reactive oxygen species (ROS). I.
Keyphrases
biomedical application hydrogen-peroxide-enhanced nonthermal plasma effluent hydrogen peroxide treatment surface index term bacteria med-ical application precise chemical concentration measurement medical clinic dbd con-figurations disinfection zone bacteria strain plasma-induced free radical nitrous oxide staphylococcus aureus technology robust plasma medicine plasma effluent 6-log reduction fre-quency comb spectroscopy novel nonthermal plasma dielectric-barrier dis-charge bacillus atrophaes spore reactive oxygen specie bactericidal property active specie free-radical effluent key variable physical distance hydrogen peroxide additive vivo multiple exposure inactivation efficacy air stream adverse effect nitrogen dioxide mouse skin
