DMCA
The Lactic Acid-Induced Acid Tolerance Response in Salmonella enterica Serovar Typhimurium Induces Sensitivity to Hydrogen Peroxide† (2006)
| Citations: | 2 - 0 self |
BibTeX
@MISC{Greenacre06thelactic,
author = {E. J. Greenacre and S. Lucchini and J. C. D. Hinton and T. F. Brocklehurst},
title = {The Lactic Acid-Induced Acid Tolerance Response in Salmonella enterica Serovar Typhimurium Induces Sensitivity to Hydrogen Peroxide†},
year = {2006}
}
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Abstract
Transcriptome analyses of Salmonella enterica serovar Typhimurium revealed that 15 genes were significantly up-regulated after 2 h of adaptation with lactic acid. cadB was the most highly up-regulated gene and was shown to be an essential component. Lactic acid-adapted cells exhibited sensitivity to hydrogen peroxide, likely due to down-regulation of the OxyR regulon. Salmonella enterica serovar Typhimurium employs both a logarithmic-phase acid tolerance response (ATR) and a sta-tionary-phase ATR to cope with acid stress (23). The logarith-mic-phase HCl-induced ATR requires both pre- and post-acid-shock adaptation phases to be fully tolerant to a pHo of 3.0 at 37°C (13). The pre-acid-shock adaptation phase occurs after exposure to pH 5.8 and involves the production of at least 12 acid shock proteins (5). The gene products of the cad operon (1) and the atp genes (6, 7) all appear to be important in this preshock adaptation phase. Salmonella commonly encounters stress from organic acids, either as by-products of its own metabolism (25), as
Keyphrases
hydrogen peroxide serovar typhimurium induces sensitivity lactic acid-induced acid tolerance response cad operon logarith-mic-phase hcl-induced atr oxyr regulon serovar typhimurium organic acid logarithmic-phase acid tolerance response gene product atp gene transcriptome analysis up-regulated gene essential component lactic acid post-acid-shock adaptation phase pre-acid-shock adaptation phase preshock adaptation phase sta-tionary-phase atr acid shock protein acid stress salmonella enterica serovar typhimurium lactic acid-adapted cell
