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Epidemiologic evidence for an association between gasoline and kidney cancer. Environ. Health Perspect. 62 (1985)
| Citations: | 6 - 0 self |
BibTeX
@MISC{Enterline85epidemiologicevidence,
author = {Philip E. Enterline and John Viren},
title = {Epidemiologic evidence for an association between gasoline and kidney cancer. Environ. Health Perspect. 62},
year = {1985}
}
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Abstract
A recent animal experiment suggests that gasoline exposure may be a cause of human kidney cancer. This is a literature review to see whether there is any epidemiologic support for these animal findings. Trends and geographic patterns in gasoline consumption and kidney cancer mortality are moderately supportive of a relationship, although this cannot be considered important evidence for a causal relationship. Most other ecological correlations are not supportive of a relationship. Eleven oil refinery populations and one population of petroleum products distribution workers have been studied. These studies taken as a group do not appear to support the notion of a relationship between gasoline exposure and kidney cancer. However, most were not designed or analyzed with this hypothesis in mind. An examination of these data which attempts to consider the ages of the populations studied provides some evidence of a small kidney cancer excess among older workers or among workers exposed for long periods. Because of the importance of gasoline and the potential for exposure by the public further study of exposed populations is needed. A chronic inhalation study has shown that unleaded gasoline vapor caused kidney carcinomas and sarcomas in male rats with some evidence of a dose-response relationship (1). Also observed was an increase in liver
Keyphrases
kidney cancer epidemiologic evidence health perspect gasoline exposure animal finding small kidney cancer excess causal relationship ecological correlation eleven oil refinery population long period geographic pattern literature review human kidney cancer important evidence epidemiologic support male rat kidney carcinoma exposed population kidney cancer mortality chronic inhalation study dose-response relationship recent animal experiment petroleum product distribution worker unleaded gasoline vapor gasoline consumption
