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...scribed above. RESULTS As a first step in assessing the efficacy of standard regimens for treatment of endophthalmitis, two parameters were systematically analyzed, the administration of the antiinflammatory corticosteroid dexamethasone and the timing of administration and the virulence of the organism causing endophthalmitis. The first set of experiments examined the value of dexamethasone as an adjunct to antimicrobial therapy in Downloaded from iovs.arvojournals.org on 06/19/2019 Dexamethasone and E. faecalis Endophthalmitis 11 Cyl-, Untreated (n=7)[l] Cyl-,NoDex(n=3)[2] Cyl-,Dex@24hrs(n=3)[3] Absolute Controls (n=4) Surgical Controls (n=6) X y V r 2 3 4 Post-Infection Day FIGURE 1. B-wave amplitude retention in eyes infected with noncytolytic Enterococcus faecalis. Amp (ampicillin, 1000 fig) and Gen (gentamicin, 200 fig) were administered at postinfection day 1 except untreated animals, absolute control animals, and surgical control animals. Dex (dexamethasone, 400 ng) was administered as described on graph. No Dex = ampicillin/gentamicin alone at postinfection day 1. Cyl— = noncytolytic E. faecalis. Absolute controls = no injection. Surgical controls = saline injection only. Numb...

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...rgical control animals. Dex (dexamethasone, 400 fig) was administered as described on graph. No Dex = ampicillin/gentamicin alone at post infection day 1. Cyl+ = cytolysin-producing E. faecalis. Numbers in boldface brackets are referred to in the text as curves 1, 2, 3, and so on. Absolute and surgical control data are included only in Figure 1 for clarity of graphs. Downloaded from iovs.arvojournals.org on 06/19/2019 12 Investigative Ophthalmology & Visual Science, January 1995, Vol. 36, No. 1 Cyl-,Dex@24hrs(n=3)[l] Cyl-,Dex@36hrs(n=3)[2] Cyl+, Dex @ 24 hrs (n=6) [3] Cyl+, Dex @ 36 hrs (n=6) [4] 1 2 3 4 5 Post-Infection Day FIGURE 3. B-wave amplitude retention in eyes infected with cytolytic or noncytolytic Enterococcus faecalis. Amp (ampicillin, 1000 fig) and Gen (gentamicin, 200 fig) were administered at post infection day 1 except absolute control and surgical control animals. Dex (dexamethasone, 400 fig) was administered as described on graph. Cyl+ = cytolysin-producing E. faecalis. Cyl— = noncytolytic E. faecalis. Numbers in boldface brackets are referred to in text as curves 1, 2, 3, and so on. Absolute control and surgical control data are included only in Figure 1 for clarity...

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...rial quantitation as described above. RESULTS As a first step in assessing the efficacy of standard regimens for treatment of endophthalmitis, two parameters were systematically analyzed, the administration of the antiinflammatory corticosteroid dexamethasone and the timing of administration and the virulence of the organism causing endophthalmitis. The first set of experiments examined the value of dexamethasone as an adjunct to antimicrobial therapy in Downloaded from iovs.arvojournals.org on 06/19/2019 Dexamethasone and E. faecalis Endophthalmitis 11 Cyl-, Untreated (n=7)[l] Cyl-,NoDex(n=3)[2] Cyl-,Dex@24hrs(n=3)[3] Absolute Controls (n=4) Surgical Controls (n=6) X y V r 2 3 4 Post-Infection Day FIGURE 1. B-wave amplitude retention in eyes infected with noncytolytic Enterococcus faecalis. Amp (ampicillin, 1000 fig) and Gen (gentamicin, 200 fig) were administered at postinfection day 1 except untreated animals, absolute control animals, and surgical control animals. Dex (dexamethasone, 400 ng) was administered as described on graph. No Dex = ampicillin/gentamicin alone at postinfection day 1. Cyl— = noncytolytic E. faecalis. Absolute controls = no injection. Surgical controls = sali...