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...f brain disorders were recruited through advertisements placed on notice boards across the University of Pécs. The handedness of all subjects was assessed by the Edinburgh Handedness Inventory (EHI) (=-=Oldfield, 1971-=-). Two individuals were excluded due to excessive head movements during the fMRI and/or DTI protocols. Thus, we included a total of 16 healthy, young (mean age: 21.8 ± 1.7; range: 20–25 years), left-h...

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...g FEAT (FMRI Expert Analysis Tool) Version 5.98, part of FSL (FMRIB’s Software Library, www.fmrib.ox.ac.uk/fsl). Pre-processing included BET brain extraction (Smith, 2002), MCFLIRT motion correction (=-=Jenkinson, Bannister, Brady, & Smith, 2002-=-), spatial smoothing with 5 mm full width at half maximum and high-pass temporal filtering with 120 s cut-off. The temporal filtering applied to the data was used for the model as well. General linear...

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... statistical analysis were performed using FEAT (FMRI Expert Analysis Tool) Version 5.98, part of FSL (FMRIB’s Software Library, www.fmrib.ox.ac.uk/fsl). Pre-processing included BET brain extraction (=-=Smith, 2002-=-), MCFLIRT motion correction (Jenkinson, Bannister, Brady, & Smith, 2002), spatial smoothing with 5 mm full width at half maximum and high-pass temporal filtering with 120 s cut-off. The temporal filt...

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...lity of water diffusion, respectively and provide unique insights into white-matter (WM) microstructure. Increased MD may result from loss of barriers such as myelin sheaths, cell membranes or axons (=-=Beaulieu, 2002-=-), while FA thought to be related to tract integrity and may reflect the alignment of neuronal fibers (Johansen-Berg & Behrens, 2009). Higher MD and lower FA values may indicate lower microstructural ...

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...latter subtracted from the former and the difference was divided by the sum of the original and flipped datasets. Finally, the left half of this dataset (corretions), with AI as variable of interest (=-=Nichols & Holmes, 2002-=-). Results were considered significant for P < 0.05, corrected for multiple comparisons using ‘‘threshold-free cluster enhancement’’ (TFCE), which avoids making an arbitrary choice of the clusterformi...

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...the data was used for the model as well. General linear model (GLM) time-series statistical analyses were carried out using FILM (FMRIB’s Improved Linear Model) with local autocorrelation correction (=-=Woolrich, Ripley, Brady, & Smith, 2001-=-). To model the blood oxygen level-dependent (BOLD) response a box-car function with ‘‘task’’ vs. ‘‘rest’’ conditions was convolved with the FSL’s canonical gamma haemodynamic response function (HRF)....

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...tani et al., 2005; Hart & Gordon, 1990; Price, 2000). Geschwind hypothesized that this area is involved in the development of language because of its importance in enhancing cross-modal associations (=-=Geschwind, 1965-=-). Lesions in this territory are associated with language related deficits, such as alexia, agraphia (Price, 2000; Sakurai, Asami, & Mannen, 2010), dyslexia (Habib, 2000) or impairments on semantic co...

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... to the fact that we are unable to noninvasively resolve fiber tracts at a microscopic level. Even though some methods have been developed to estimate and differentiate multiple fibers in each voxel (=-=Behrens, Berg, Jbabdi, Rushworth, & Woolrich, 2007-=-; Tuch, Reese, Wiegell, & Wedeen, 2003), the challenge of complex fiber structures has not been completely resolved. It is likely that the centers of fiber bundles analysed by TBSS are more compactly ...

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...or parietal cortex (including the angular gyrus) is suggested to have a main role in language comprehension and thought to be related to semantic processing (Catani et al., 2005; Hart & Gordon, 1990; =-=Price, 2000-=-). Geschwind hypothesized that this area is involved in the development of language because of its importance in enhancing cross-modal associations (Geschwind, 1965). Lesions in this territory are ass...

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...degrees-of-freedom linear fit) using FLIRT (Jenkinson et al., 2002). Subsequently, the registration from structural image to the standard space was further refined using FNIRT nonlinear registration (=-=Andersson, Jenkinson, & Smith, 2007-=-a,b). The resulting linear and non-linear deformations were combined mathematically and applied to the first-level statistical maps to transform them into standard space. Interpolation was only used i...

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...sons using ‘‘threshold-free cluster enhancement’’ (TFCE), which avoids making an arbitrary choice of the clusterforming threshold, while preserving the sensitivity benefits of clusterwise correction (=-=Smith & Nichols, 2009-=-). White-matter atlases provided with FSL version 4.1.8 (JHU ICBM-DTI-81 white-matter labels atlas and JHU white-matter tractography atlas) and the second edition of the MRI Atlas of Human White Matte...

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...e lateralization. Language lateralization showed positive correlation with FA and negative correlation with MD in the left AnG-WM close to the region recently termed as the ‘‘Geschwind’s territory’’ (=-=Catani, Jones, & Ffytche, 2005-=-). The Geschwind’s territory/inferior parietal cortex (including the angular gyrus) is suggested to have a main role in language comprehension and thought to be related to semantic processing (Catani ...

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... cross-modal associations (Geschwind, 1965). Lesions in this territory are associated with language related deficits, such as alexia, agraphia (Price, 2000; Sakurai, Asami, & Mannen, 2010), dyslexia (=-=Habib, 2000-=-) or impairments on semantic comprehension tasks (Hart & Gordon, 1990; Price, 2000). Functional magnetic resonance imaging studies demonstrated greater angular gyrus BOLD-signal in response to the pro...

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... (http://www.fmrib.ox.ac.uk/fsl/fdt) was used to generate voxelwise images of fractional anisotropy (FA) and mean diffusivity (MD) by fitting a diffusion tensor model to the data at each brain voxel (=-=Smith et al., 2004-=-). Image analysis was carried out using Tract-Based Spatial Statistics (TBSS v1.2) (Smith et al., 2006). First, all subjects’ FA data were nonlinearly aligned to a high-resolution standard space avera...

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...olve fiber tracts at a microscopic level. Even though some methods have been developed to estimate and differentiate multiple fibers in each voxel (Behrens, Berg, Jbabdi, Rushworth, & Woolrich, 2007; =-=Tuch, Reese, Wiegell, & Wedeen, 2003-=-), the challenge of complex fiber structures has not been completely resolved. It is likely that the centers of fiber bundles analysed by TBSS are more compactly packed with less complex fiber orienta...

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...brain running lateral to the corticospinal tract interconnecting frontal, temporal and parietal association areas, which emphasizes its centrality to many associative or higher order brain functions (=-=Makris et al., 2005-=-). Four different components of the SLF have been recently proposed (Makris et al., 2005). All of them have a frontal terminus in the posterior part of the frontal lobe, but they differ in their origi...

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... resonance imaging studies demonstrated greater angular gyrus BOLD-signal in response to the processing of words than nonwords (Binder, Medler, Desai, Conant, & Liebenthal, 2005; Binder et al., 2003; =-=Rissman, Eliassen, & Blumstein, 2003-=-) and for normal G. Perlaki et al. / Brain andcompared to semantically incongruent sentences (Humphries, Binder, Medler, & Liebenthal, 2007). Although, the relevance of angular gyrus is obvious, the s...

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...enon & Desmond, 2001), it is not a typical language area; it is rather related to sensorimotor integration by maintaining an internal representation of the state of both the world and one’s own body (=-=Wolpert, Goodbody, & Husain, 1998-=-). It has also been reported previously that parietal lobe functional specialization is correlated with language lateralization, however it may neither explain this finding altogether (Badzakova-Trajk...

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...are not directly comparable to our one. Schizophrenic patients showed microstructural changes in the SLF (somewhat larger effect in the left SLF) compared to healthy controls (Buchsbaum et al., 2006; =-=Foong et al., 2000-=-; Karlsgodt et al., 2008; Kong et al., 2011). Language lateralization was also found to be more atypical in schizophrenia (Sommer, Ramsey, & Kahn, 2001; van Veelen et al., 2011). Considering our prese...

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...nd’s territory/inferior parietal cortex (including the angular gyrus) is suggested to have a main role in language comprehension and thought to be related to semantic processing (Catani et al., 2005; =-=Hart & Gordon, 1990-=-; Price, 2000). Geschwind hypothesized that this area is involved in the development of language because of its importance in enhancing cross-modal associations (Geschwind, 1965). Lesions in this terr...

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..., the incidence of atypical (bilateral or right-hemispheric) language lateralization was found to increase in left-handers to approximately 15–30% (Josse & Tzourio-Mazoyer, 2004; Knecht et al., 2000; =-=Pujol et al., 1999-=-). Despite the fact that hemispheric language lateralization of the human brain is a hot topic in neuroscience for a long time, its neuroanatomy is not fully understood (Propper et al., 2010; Vernooij...

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...nry, 1985). Genetic theories of handedness and brain asymmetry were also suggested assuming a genetic predisposition toward right-handedness and left-hemispheric dominance for language (Annett, 2002; =-=McManus, 2002-=-). Left-handedness may be related to certain psychiatric diseases cessing is one of 09; Josse & ateralizatio dedness: 9 of right-handed subjects showed left-hemispheric dom while 4–6% showed a bilater...

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...uchel et al., 2004; Westerhausen et al., 2003, 2004), aging (Abe et al., 2008; Camara, Bodammer, Rodriguez-Fornells, & Tempelmann, 2007; Hsu et al., 2008) or sex-specific differences in WM integrity (=-=Catani et al., 2007-=-; Hagmann et al., 2006; Menzler et al., 2011; Thiebaut de Schotten et al., 2011) as well as the impact of interaction between gender and handedness (Hagmann et al., 2006), only left-handed, healthy, y...

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.... Functional magnetic resonance imaging studies demonstrated greater angular gyrus BOLD-signal in response to the processing of words than nonwords (Binder, Medler, Desai, Conant, & Liebenthal, 2005; =-=Binder et al., 2003-=-; Rissman, Eliassen, & Blumstein, 2003) and for normal G. Perlaki et al. / Brain andcompared to semantically incongruent sentences (Humphries, Binder, Medler, & Liebenthal, 2007). Although, the releva...

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...nder, Medler, Desai, Conant, & Liebenthal, 2005; Binder et al., 2003; Rissman, Eliassen, & Blumstein, 2003) and for normal G. Perlaki et al. / Brain andcompared to semantically incongruent sentences (=-=Humphries, Binder, Medler, & Liebenthal, 2007-=-). Although, the relevance of angular gyrus is obvious, the specific function of this area in languagecomprehension remains to be clarified (Brownsett & Wise, 2010). It is usually considered as a part...

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...anding the boundaries of the canonical language network such as the inferior longitudinal fasciculus, the uncinate fasciculus and the inferior fronto-occipital fasciculus may be relevant to language (=-=Catani & Mesulam, 2008-=-). However, our data indicate a lack of significance of these additional regions in relation to language lateralization. Language lateralization showed positive correlation with FA and negative correl...

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... established with fMRI. In order to increase the chances of including individuals exhibiting atypical language lateralization (Szaflarski et al., 2002) and to avoid confounding effects of handedness (=-=Buchel et al., 2004-=-; Westerhausen et al., 2003, 2004), aging (Abe et al., 2008; Camara, Bodammer, Rodriguez-Fornells, & Tempelmann, 2007; Hsu et al., 2008) or sex-specific differences in WM integrity (Catani et al., 200...

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... Kitazawa, 2000; Phillips, Lowe, Lurito, Dzemidzic, & Mathews, 2001; Vikingstad, George, Johnson, & Cao, 2000), whereas others found no sex difference in language lateralization (Knecht et al., 2000; =-=Sommer, Aleman, Bouma, & Kahn, 2004-=-). The ROI used for AI calculation was symmetric across the 326 G. Perlaki et al. / Brain andthis study. Our results may offer new insights into language lateralization and structure–function relation...

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...s mirrored image. The ROI was symmetric across the cerebral hemispheres with respect to size, shape and number of voxels to allow unbiased calculation of AI. AIs were calculated using the LI-toolbox (=-=Wilke & Lidzba, 2007-=-) available as part of the SPM8 software package (Wellcome Trust Centre for Neuroimaging, London, UK, http://www.fil.ion.ucl.ac.uk/spm/software/spm8/) for the frontal lobe mask created above (excludin...

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... be a consequence of the fact that only women were included in the present study (whereas previous data based on both women and men). Some studies indicate that language is less lateralized in women (=-=Kansaku, Yamaura, & Kitazawa, 2000-=-; Phillips, Lowe, Lurito, Dzemidzic, & Mathews, 2001; Vikingstad, George, Johnson, & Cao, 2000), whereas others found no sex difference in language lateralization (Knecht et al., 2000; Sommer, Aleman,...

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... Moffat, Hampson, & Lee, 1998), insula (Keller et al., 2011), right hippocampus (Jansen et al., 2010) or left planum temporale (Josse, Mazoyer, Crivello, & Tzourio-Mazoyer, 2003; Moffat et al., 1998; =-=Tzourio, Nkanga-Ngila, & Mazoyer, 1998-=-). WM microstructure in relation to language lateralization has also been recently investigated using the combination of functional magnetic resonance imaging (fMRI) and DTI techniques (Häberling, Bad...

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...chiatric diseases cessing is one of 09; Josse & ateralizatio dedness: 9 of right-handed subjects showed left-hemispheric dom while 4–6% showed a bilateral pattern (Pujol, Deus, Losilla, devila, 1999; =-=Springer et al., 1999-=-). In contrast, the incidence of atypical (bilateral or right-hemispheric) language lateralization was found to increase in left-handers to approximately 15–30% (Josse & Tzourio-Mazoyer, 2004; Knecht ...

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...50 to 100) women. The study was approved by the Regional Ethical Committee of the University of Pécs and performed in accordance with the ethical standards described in the Declaration of Helsinki (=-=Rickham, 1964-=-). All subjects got detailed information about the investigation in both oral and written forms and gave written informed consent prior to the study. 2.2. Imaging data acquisition and visual analysis ...

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.... Introduction The incidence of left-handedness, ranging from moderate through strong left-handed is about 10% in the population (Gilbert (especially schizophrenia and bipolar disorders) (Klar, 1999; =-=Satz & Green, 1999-=-), developmental disorders (Dane & Balci, 2007; Goez & Zelnik, 2008) and central nervous system disorders (Llaurens, Raymond, & Faurie, 2009).gDepartment of General Linguistics, University hDepartment...

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...degrees-of-freedom linear fit) using FLIRT (Jenkinson et al., 2002). Subsequently, the registration from structural image to the standard space was further refined using FNIRT nonlinear registration (=-=Andersson, Jenkinson, & Smith, 2007-=-a,b). The resulting linear and non-linear deformations were combined mathematically and applied to the first-level statistical maps to transform them into standard space. Interpolation was only used i...

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...ion paradigminterest), in relation to hemispheric language lateralization established with fMRI. In order to increase the chances of including individuals exhibiting atypical language lateralization (=-=Szaflarski et al., 2002-=-) and to avoid confounding effects of handedness (Buchel et al., 2004; Westerhausen et al., 2003, 2004), aging (Abe et al., 2008; Camara, Bodammer, Rodriguez-Fornells, & Tempelmann, 2007; Hsu et al., ...

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...functional language lateralization and the morphometric magnetic resonance imaging (MRI) findings of arcuate fasciculus (Propper et al., 2010), corpus callosum (Josse, Seghier, Kherif, & Price, 2008; =-=Moffat, Hampson, & Lee, 1998-=-), insula (Keller et al., 2011), right hippocampus (Jansen et al., 2010) or left planum temporale (Josse, Mazoyer, Crivello, & Tzourio-Mazoyer, 2003; Moffat et al., 1998; Tzourio, Nkanga-Ngila, & Mazo...

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...cluding individuals exhibiting atypical language lateralization (Szaflarski et al., 2002) and to avoid confounding effects of handedness (Buchel et al., 2004; Westerhausen et al., 2003, 2004), aging (=-=Abe et al., 2008-=-; Camara, Bodammer, Rodriguez-Fornells, & Tempelmann, 2007; Hsu et al., 2008) or sex-specific differences in WM integrity (Catani et al., 2007; Hagmann et al., 2006; Menzler et al., 2011; Thiebaut de ...

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...a, devila, 1999; Springer et al., 1999). In contrast, the incidence of atypical (bilateral or right-hemispheric) language lateralization was found to increase in left-handers to approximately 15–30% (=-=Josse & Tzourio-Mazoyer, 2004-=-; Knecht et al., 2000; Pujol et al., 1999). Despite the fact that hemispheric language lateralization of the human brain is a hot topic in neuroscience for a long time, its neuroanatomy is not fully u...

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... language lateralization has also been recently investigated using the combination of functional magnetic resonance imaging (fMRI) and DTI techniques (Häberling, Badzakova-Trajkov, & Corballis, 2011; =-=Powell et al., 2006-=-; Vernooij et al., 2007; Westerhausen et al., 2006). These studies tested for associations between the lateralization of fMRI activations and various diffusion tensor measures (fractional anisotropy, ...

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... data. First-level statistical maps were thresholded using clusters determined by Z > 2.3 and a corrected cluster significance threshold of P = 0.05 to assess fMRI activations in main language areas (=-=Worsley, 2001-=-). Single-session data sets were registered into standard space prior to language asymmetry index (AI) calculation using a threestep process. First, low-resolution fMRI data from each subject were reg...

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...et al., 2002) and to avoid confounding effects of handedness (Buchel et al., 2004; Westerhausen et al., 2003, 2004), aging (Abe et al., 2008; Camara, Bodammer, Rodriguez-Fornells, & Tempelmann, 2007; =-=Hsu et al., 2008-=-) or sex-specific differences in WM integrity (Catani et al., 2007; Hagmann et al., 2006; Menzler et al., 2011; Thiebaut de Schotten et al., 2011) as well as the impact of interaction between gender a...

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...a significant positive association between language lateralization and FA (Spearman’s rank correlation, rho = 0.547, P = 0.028). Although left superior parietal lobe has an essential role in writing (=-=Menon & Desmond, 2001-=-), it is not a typical language area; it is rather related to sensorimotor integration by maintaining an internal representation of the state of both the world and one’s own body (Wolpert, Goodbody, &...

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...along with the SLF II fibers. Although the arcuate fasciculus is just a component of the superior longitudinal fasciculus, their names are often interchanged in the literature (Bernal & Altman, 2010; =-=Bernal & Ardila, 2009-=-; Makris et al., 2005). According to the conventional model of language organization, the arcuate fasciculus connects the language areas of Broca and Wernicke (Bernal & Altman, 2010; Catani &Mesulam, ...

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...prehension tasks (Hart & Gordon, 1990; Price, 2000). Functional magnetic resonance imaging studies demonstrated greater angular gyrus BOLD-signal in response to the processing of words than nonwords (=-=Binder, Medler, Desai, Conant, & Liebenthal, 2005-=-; Binder et al., 2003; Rissman, Eliassen, & Blumstein, 2003) and for normal G. Perlaki et al. / Brain andcompared to semantically incongruent sentences (Humphries, Binder, Medler, & Liebenthal, 2007)....

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...ment (Jansen et al., 2006), classification of language lateralization based on this task is consistent with the Wada test, which is the ‘‘gold-standard’’ for measuring hemispheric language dominance (=-=Adcock, Wise, Oxbury, Oxbury, & Matthews, 2003-=-; Woermann et al., 2003; Yetkin et al., 1998). Moreover, the fMRI asymmetry indices are reproducible in patients as well as in controls (Adcock et al., 2003). The paradigm included seven cycles of 30 ...

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...nly women were included in the present study (whereas previous data based on both women and men). Some studies indicate that language is less lateralized in women (Kansaku, Yamaura, & Kitazawa, 2000; =-=Phillips, Lowe, Lurito, Dzemidzic, & Mathews, 2001-=-; Vikingstad, George, Johnson, & Cao, 2000), whereas others found no sex difference in language lateralization (Knecht et al., 2000; Sommer, Aleman, Bouma, & Kahn, 2004). The ROI used for AI calculati...

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...esterhausen et al., 2003, 2004), aging (Abe et al., 2008; Camara, Bodammer, Rodriguez-Fornells, & Tempelmann, 2007; Hsu et al., 2008) or sex-specific differences in WM integrity (Catani et al., 2007; =-=Hagmann et al., 2006-=-; Menzler et al., 2011; Thiebaut de Schotten et al., 2011) as well as the impact of interaction between gender and handedness (Hagmann et al., 2006), only left-handed, healthy, young women were recrui...

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... reserved. 1. Introduction The incidence of left-handedness, ranging from moderate through strong left-handed is about 10% in the population (Gilbert (especially schizophrenia and bipolar disorders) (=-=Klar, 1999-=-; Satz & Green, 1999), developmental disorders (Dane & Balci, 2007; Goez & Zelnik, 2008) and central nervous system disorders (Llaurens, Raymond, & Faurie, 2009).gDepartment of General Linguistics, Un...

Citation Context

...ion (Gilbert (especially schizophrenia and bipolar disorders) (Klar, 1999; Satz & Green, 1999), developmental disorders (Dane & Balci, 2007; Goez & Zelnik, 2008) and central nervous system disorders (=-=Llaurens, Raymond, & Faurie, 2009-=-).gDepartment of General Linguistics, University hDepartment of Neurosurgery, University of Pe a r t i c l e i n f o Article history: Accepted 20 May 2013 Available online 21 June 2013 Keywords: Diffu...

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...dyck & Petrinovich, 1977). Several type of factors may affect the development of left-handedness including maternal handedness and familiar history of sinistrality (Annett, 1983; Knecht et al., 2000; =-=McKeever, 2000-=-), gender (Gilbert & WyLeft-hemispheric preference for language pro the most consistent early findings (Auer et al., 20 rio-Mazoyer, 2004). Hemispheric language l shown to be systematically associated...

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...be influenced (Vos, Jones, Jeurissen, Viergever, & Leemans, 2012). This issue is not limited to our methodology only (Cubon, Putukian, Boyer, & Dettwiler, 2011; Giorgio et al., 2010; Li et al., 2010; =-=Takao, Hayashi, & Ohtomo, 2011-=-) and is due to the fact that we are unable to noninvasively resolve fiber tracts at a microscopic level. Even though some methods have been developed to estimate and differentiate multiple fibers in ...

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...ions with more than one dominant orientation), therefore the directionally dependent diffusion measure (FA) as well as the scalar measure of the total diffusion within a voxel (MD) may be influenced (=-=Vos, Jones, Jeurissen, Viergever, & Leemans, 2012-=-). This issue is not limited to our methodology only (Cubon, Putukian, Boyer, & Dettwiler, 2011; Giorgio et al., 2010; Li et al., 2010; Takao, Hayashi, & Ohtomo, 2011) and is due to the fact that we a...

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...partment of Radiology, Hospital Markusovsz fDepartment of Psychiatry and Psychotherapy, Universit of Pecs, I cs, Ret u. socki, 1992), testosterone level (Tan, 1991) and history of early brain injury (=-=Satz, Orsini, Saslow, & Henry, 1985-=-). Genetic theories of handedness and brain asymmetry were also suggested assuming a genetic predisposition toward right-handedness and left-hemispheric dominance for language (Annett, 2002; McManus, ...

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...he NMR Forschungs GmbH am Max-Plan eCentral Department of Radiology, Hospital Markusovsz fDepartment of Psychiatry and Psychotherapy, Universit of Pecs, I cs, Ret u. socki, 1992), testosterone level (=-=Tan, 1991-=-) and history of early brain injury (Satz, Orsini, Saslow, & Henry, 1985). Genetic theories of handedness and brain asymmetry were also suggested assuming a genetic predisposition toward right-handedn...

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...nguage lateralization based on this task is consistent with the Wada test, which is the ‘‘gold-standard’’ for measuring hemispheric language dominance (Adcock, Wise, Oxbury, Oxbury, & Matthews, 2003; =-=Woermann et al., 2003-=-; Yetkin et al., 1998). Moreover, the fMRI asymmetry indices are reproducible in patients as well as in controls (Adcock et al., 2003). The paradigm included seven cycles of 30 second long rest altern...

Citation Context

...to assess functional hemispheric language lateralization (Auer et al., 2009; Janszky et al., 2003). Although Cogthere are some questions regarding the reliability of fMRI-based laterality assessment (=-=Jansen et al., 2006-=-), classification of language lateralization based on this task is consistent with the Wada test, which is the ‘‘gold-standard’’ for measuring hemispheric language dominance (Adcock, Wise, Oxbury, Oxb...

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...SLF) compared to healthy controls (Buchsbaum et al., 2006; Foong et al., 2000; Karlsgodt et al., 2008; Kong et al., 2011). Language lateralization was also found to be more atypical in schizophrenia (=-=Sommer, Ramsey, & Kahn, 2001-=-; van Veelen et al., 2011). Considering our present results that microstructural organization of the left SLF are related to language lateralization in healthy subjects, we might hypothesize that atyp...

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...eral prefrontal cortex along with the SLF II fibers. Although the arcuate fasciculus is just a component of the superior longitudinal fasciculus, their names are often interchanged in the literature (=-=Bernal & Altman, 2010-=-; Bernal & Ardila, 2009; Makris et al., 2005). According to the conventional model of language organization, the arcuate fasciculus connects the language areas of Broca and Wernicke (Bernal & Altman, ...

Citation Context

...the asymmetry values highly depend on the applied threshold (Suarez, Whalen, O’Shea, & Golby, 2008), the robust and stable weighted bootstrapping method was used to generate threshold-free AI values (=-=Wilke & Schmithorst, 2006-=-). Positive AI values represent left-hemispheric language lateralization; negative ones indicate right-hemispheric lateralization. Language dominance was classified as left hemispheric (AI > 0.2), bil...

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... & Husain, 1998). It has also been reported previously that parietal lobe functional specialization is correlated with language lateralization, however it may neither explain this finding altogether (=-=Badzakova-Trajkov, Häberling, Roberts, & Corballis, 2010-=-). Integrating this result into current theories of language is not easy, but our observation in the left SPL-WM may suggest an important direction for future research of WM microstructural changes un...

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...r et al., 2010), corpus callosum (Josse, Seghier, Kherif, & Price, 2008; Moffat, Hampson, & Lee, 1998), insula (Keller et al., 2011), right hippocampus (Jansen et al., 2010) or left planum temporale (=-=Josse, Mazoyer, Crivello, & Tzourio-Mazoyer, 2003-=-; Moffat et al., 1998; Tzourio, Nkanga-Ngila, & Mazoyer, 1998). WM microstructure in relation to language lateralization has also been recently investigated using the combination of functional magneti...

Citation Context

... studies reported relationship between functional language lateralization and the morphometric magnetic resonance imaging (MRI) findings of arcuate fasciculus (Propper et al., 2010), corpus callosum (=-=Josse, Seghier, Kherif, & Price, 2008-=-; Moffat, Hampson, & Lee, 1998), insula (Keller et al., 2011), right hippocampus (Jansen et al., 2010) or left planum temporale (Josse, Mazoyer, Crivello, & Tzourio-Mazoyer, 2003; Moffat et al., 1998;...

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...s previous data based on both women and men). Some studies indicate that language is less lateralized in women (Kansaku, Yamaura, & Kitazawa, 2000; Phillips, Lowe, Lurito, Dzemidzic, & Mathews, 2001; =-=Vikingstad, George, Johnson, & Cao, 2000-=-), whereas others found no sex difference in language lateralization (Knecht et al., 2000; Sommer, Aleman, Bouma, & Kahn, 2004). The ROI used for AI calculation was symmetric across the 326 G. Perlaki...

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...I. In order to increase the chances of including individuals exhibiting atypical language lateralization (Szaflarski et al., 2002) and to avoid confounding effects of handedness (Buchel et al., 2004; =-=Westerhausen et al., 2003-=-, 2004), aging (Abe et al., 2008; Camara, Bodammer, Rodriguez-Fornells, & Tempelmann, 2007; Hsu et al., 2008) or sex-specific differences in WM integrity (Catani et al., 2007; Hagmann et al., 2006; Me...

Citation Context

..., Saslow, & Henry, 1985). Genetic theories of handedness and brain asymmetry were also suggested assuming a genetic predisposition toward right-handedness and left-hemispheric dominance for language (=-=Annett, 2002-=-; McManus, 2002). Left-handedness may be related to certain psychiatric diseases cessing is one of 09; Josse & ateralizatio dedness: 9 of right-handed subjects showed left-hemispheric dom while 4–6% s...

Citation Context

... finding, these studies are not directly comparable to our one. Schizophrenic patients showed microstructural changes in the SLF (somewhat larger effect in the left SLF) compared to healthy controls (=-=Buchsbaum et al., 2006-=-; Foong et al., 2000; Karlsgodt et al., 2008; Kong et al., 2011). Language lateralization was also found to be more atypical in schizophrenia (Sommer, Ramsey, & Kahn, 2001; van Veelen et al., 2011). C...

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...typical language-lateralization might lie in interhemispheric inhibition, suggesting that left-hemispheric inhibition of right hemisphere may partly contribute to language dominance on the left side (=-=Thiel et al., 2006-=-). Reduced WM integrity of the left-hemispheric language related tracts may imply less inhibition of right-sided language areas. We found no evidence that right-hemispheric WM microstructure is relate...

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...nt sentences (Humphries, Binder, Medler, & Liebenthal, 2007). Although, the relevance of angular gyrus is obvious, the specific function of this area in languagecomprehension remains to be clarified (=-=Brownsett & Wise, 2010-=-). It is usually considered as a part of a distributed language network, but it is also conceivable that this region is repeatedly observed in certain studies of language, because it is a part of a di...

Citation Context

...y to this work.& Wysocki, 1992; Hardyck & Petrinovich, 1977). Several type of factors may affect the development of left-handedness including maternal handedness and familiar history of sinistrality (=-=Annett, 1983-=-; Knecht et al., 2000; McKeever, 2000), gender (Gilbert & WyLeft-hemispheric preference for language pro the most consistent early findings (Auer et al., 20 rio-Mazoyer, 2004). Hemispheric language l ...

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...otal diffusion within a voxel (MD) may be influenced (Vos, Jones, Jeurissen, Viergever, & Leemans, 2012). This issue is not limited to our methodology only (Cubon, Putukian, Boyer, & Dettwiler, 2011; =-=Giorgio et al., 2010-=-; Li et al., 2010; Takao, Hayashi, & Ohtomo, 2011) and is due to the fact that we are unable to noninvasively resolve fiber tracts at a microscopic level. Even though some methods have been developed ...

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...rate through strong left-handed is about 10% in the population (Gilbert (especially schizophrenia and bipolar disorders) (Klar, 1999; Satz & Green, 1999), developmental disorders (Dane & Balci, 2007; =-=Goez & Zelnik, 2008-=-) and central nervous system disorders (Llaurens, Raymond, & Faurie, 2009).gDepartment of General Linguistics, University hDepartment of Neurosurgery, University of Pe a r t i c l e i n f o Article hi...

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... Mazoyer, 1998). WM microstructure in relation to language lateralization has also been recently investigated using the combination of functional magnetic resonance imaging (fMRI) and DTI techniques (=-=Häberling, Badzakova-Trajkov, & Corballis, 2011-=-; Powell et al., 2006; Vernooij et al., 2007; Westerhausen et al., 2006). These studies tested for associations between the lateralization of fMRI activations and various diffusion tensor measures (fr...

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...ominant twins showed leftward and the right-cerebrally dominant co-twins showed rightward asymmetry of anisotropic diffusion, indicating a strong nongenetic influence in arcuate fasciculus asymmetry (=-=Häberling, Badzakova-Trajkov, & Corballis, 2013-=-). However, none of these studies provided insights into the relationship of WM microstructure and language lateralization at the whole-brain level. Tract-based spatial statistics (TBSS) is a new appr...

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...; 60 axial nition 82 (2013) 319–328As in our previous studies, a standard verbal fluency task with a block design was used to assess functional hemispheric language lateralization (Auer et al., 2009; =-=Janszky et al., 2003-=-). Although Cogthere are some questions regarding the reliability of fMRI-based laterality assessment (Jansen et al., 2006), classification of language lateralization based on this task is consistent ...

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...the morphometric magnetic resonance imaging (MRI) findings of arcuate fasciculus (Propper et al., 2010), corpus callosum (Josse, Seghier, Kherif, & Price, 2008; Moffat, Hampson, & Lee, 1998), insula (=-=Keller et al., 2011-=-), right hippocampus (Jansen et al., 2010) or left planum temporale (Josse, Mazoyer, Crivello, & Tzourio-Mazoyer, 2003; Moffat et al., 1998; Tzourio, Nkanga-Ngila, & Mazoyer, 1998). WM microstructure ...

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...tly investigated using the combination of functional magnetic resonance imaging (fMRI) and DTI techniques (Häberling, Badzakova-Trajkov, & Corballis, 2011; Powell et al., 2006; Vernooij et al., 2007; =-=Westerhausen et al., 2006-=-). These studies tested for associations between the lateralization of fMRI activations and various diffusion tensor measures (fractional anisotropy, relative anisotropy, relative fiber density, mean ...

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...s exhibiting atypical language lateralization (Szaflarski et al., 2002) and to avoid confounding effects of handedness (Buchel et al., 2004; Westerhausen et al., 2003, 2004), aging (Abe et al., 2008; =-=Camara, Bodammer, Rodriguez-Fornells, & Tempelmann, 2007-=-; Hsu et al., 2008) or sex-specific differences in WM integrity (Catani et al., 2007; Hagmann et al., 2006; Menzler et al., 2011; Thiebaut de Schotten et al., 2011) as well as the impact of interactio...

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...ng (MRI) findings of arcuate fasciculus (Propper et al., 2010), corpus callosum (Josse, Seghier, Kherif, & Price, 2008; Moffat, Hampson, & Lee, 1998), insula (Keller et al., 2011), right hippocampus (=-=Jansen et al., 2010-=-) or left planum temporale (Josse, Mazoyer, Crivello, & Tzourio-Mazoyer, 2003; Moffat et al., 1998; Tzourio, Nkanga-Ngila, & Mazoyer, 1998). WM microstructure in relation to language lateralization ha...

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...zophrenic patients showed microstructural changes in the SLF (somewhat larger effect in the left SLF) compared to healthy controls (Buchsbaum et al., 2006; Foong et al., 2000; Karlsgodt et al., 2008; =-=Kong et al., 2011-=-). Language lateralization was also found to be more atypical in schizophrenia (Sommer, Ramsey, & Kahn, 2001; van Veelen et al., 2011). Considering our present results that microstructural organizatio...

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...a voxel (MD) may be influenced (Vos, Jones, Jeurissen, Viergever, & Leemans, 2012). This issue is not limited to our methodology only (Cubon, Putukian, Boyer, & Dettwiler, 2011; Giorgio et al., 2010; =-=Li et al., 2010-=-; Takao, Hayashi, & Ohtomo, 2011) and is due to the fact that we are unable to noninvasively resolve fiber tracts at a microscopic level. Even though some methods have been developed to estimate and d...

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...uage because of its importance in enhancing cross-modal associations (Geschwind, 1965). Lesions in this territory are associated with language related deficits, such as alexia, agraphia (Price, 2000; =-=Sakurai, Asami, & Mannen, 2010-=-), dyslexia (Habib, 2000) or impairments on semantic comprehension tasks (Hart & Gordon, 1990; Price, 2000). Functional magnetic resonance imaging studies demonstrated greater angular gyrus BOLD-signa...

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...(TR/TE = 6700/78 ms; 60 axial nition 82 (2013) 319–328As in our previous studies, a standard verbal fluency task with a block design was used to assess functional hemispheric language lateralization (=-=Auer et al., 2009-=-; Janszky et al., 2003). Although Cogthere are some questions regarding the reliability of fMRI-based laterality assessment (Jansen et al., 2006), classification of language lateralization based on th...