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...prominent apical snouts and [7] secretions with atypia Columnar cell change with atypiaa [12] Columnar cell hyperplasia with atypiaa [12] Ductal intraepithelial neoplasia of the flat monomorphic type =-=[8]-=- Hypersecretory hyperplasia with atypia (some examples) [9] Pretubular hyperplasia [10] Small ectatic ducts lined by atypical ductal cells with [11] apocrine snouts a Preferred diagnostic terms. some ...

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...pithelial atypia [2–11] (Table 1), for practical purposes these lesions can be grouped into one of two diagnostic categories: columnar cell change with atypia or columnar cell hyperplasia with atypia =-=[12]-=-. Although ‘flat epithelial atypia’ will be used for purposes of discussion in the present review, we use the more specific diagnostic terms ‘columnar cell change with atypia’ and ‘columnar cell hyper...

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...hin the category of flat epithelial atypia Description Reference Atypical cystic duct [2] Atypical cystic lobules [3] Atypical lobules type A (some examples) [4] Clinging carcinoma (monomorphic type) =-=[5,6]-=- Columnar alteration with prominent apical snouts and [7] secretions with atypia Columnar cell change with atypiaa [12] Columnar cell hyperplasia with atypiaa [12] Ductal intraepithelial neoplasia of ...

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...rence Atypical cystic duct [2] Atypical cystic lobules [3] Atypical lobules type A (some examples) [4] Clinging carcinoma (monomorphic type) [5,6] Columnar alteration with prominent apical snouts and =-=[7]-=- secretions with atypia Columnar cell change with atypiaa [12] Columnar cell hyperplasia with atypiaa [12] Ductal intraepithelial neoplasia of the flat monomorphic type [8] Hypersecretory hyperplasia ...

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...ed that the cells comprising some flat atypical lesions are cytologically similar to or identical to the cells comprising some forms of DCIS or to the cells comprising the glands of tubular carcinoma =-=[6,8,10,11,18]-=-. Oyama and colleagues further noted an immunophenotypic identity between atypical cystic lobules and coexistent low-grade DCIS (the cells of both lesions being 265Breast Cancer Research Vol 5 No 5 S...

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...re evident in some of the nuclei (hematoxylin & eosin, original magnification 40×).Available online http://breast-cancer-research.com/content/5/5/263 Figure 2 [3,15,16] and the progesterone receptor =-=[13]-=- in the majority of the cells. These cells also show strong cytoplasmic expression of the bcl-2 protein [15] and variable expression of cyclin D1 [13]. In most examples of flat epithelial atypia, very...

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...hin the category of flat epithelial atypia Description Reference Atypical cystic duct [2] Atypical cystic lobules [3] Atypical lobules type A (some examples) [4] Clinging carcinoma (monomorphic type) =-=[5,6]-=- Columnar alteration with prominent apical snouts and [7] secretions with atypia Columnar cell change with atypiaa [12] Columnar cell hyperplasia with atypiaa [12] Ductal intraepithelial neoplasia of ...

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...toplasmic ratio is increased. Nucleoli are evident in some of the nuclei (hematoxylin & eosin, original magnification 40×).Available online http://breast-cancer-research.com/content/5/5/263 Figure 2 =-=[3,15,16]-=- and the progesterone receptor [13] in the majority of the cells. These cells also show strong cytoplasmic expression of the bcl-2 protein [15] and variable expression of cyclin D1 [13]. In most examp...

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...it expression of cytokeratin 19 [13], and they consistently lack expression of high molecular weight cytokeratins as defined by antibody 34 beta E-12 and antibodies to cytokeratin 5 and cytokeratin 6 =-=[14]-=- (Carlo V, Fraser J, Pliss N, Connolly JL, Schnitt S, unpublished data, 2003). In addition, the cells typically show intense nuclear expression of the estrogen receptor Clinical significance Assessmen...

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...n a core needle biopsy specimen, subsequent excision shows a more advanced lesion in about one-third of cases. This is sufficiently frequent to recommend excision in such cases as a matter of routine =-=[20,21]-=-. The presence of flat epithelial atypia in an excisional biopsy specimen should prompt a careful search for areasAvailable online http://breast-cancer-research.com/content/5/5/263 with diagnostic fe...

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...mnar cell change with atypiaa [12] Columnar cell hyperplasia with atypiaa [12] Ductal intraepithelial neoplasia of the flat monomorphic type [8] Hypersecretory hyperplasia with atypia (some examples) =-=[9]-=- Pretubular hyperplasia [10] Small ectatic ducts lined by atypical ductal cells with [11] apocrine snouts a Preferred diagnostic terms. some cases, may be prominent or exaggerated, which may impart an...

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...een the flat lesion and the DCIS. Weidner described a lesion composed of small ectatic ducts lined by one or two layers of columnar cells with apical snouts similar to those seen in tubular carcinoma =-=[17]-=-. He considered this flat lesion to represent an example of low-grade DCIS. In a more detailed analysis, Goldstein and O’Malley found an association between a similar lesion they called “small ectatic...

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... carcinoma in situ. 263Breast Cancer Research Vol 5 No 5 Schnitt Table 1 Other names used to describe lesions within the category of flat epithelial atypia Description Reference Atypical cystic duct =-=[2]-=- Atypical cystic lobules [3] Atypical lobules type A (some examples) [4] Clinging carcinoma (monomorphic type) [5,6] Columnar alteration with prominent apical snouts and [7] secretions with atypia Col...

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...aa [12] Columnar cell hyperplasia with atypiaa [12] Ductal intraepithelial neoplasia of the flat monomorphic type [8] Hypersecretory hyperplasia with atypia (some examples) [9] Pretubular hyperplasia =-=[10]-=- Small ectatic ducts lined by atypical ductal cells with [11] apocrine snouts a Preferred diagnostic terms. some cases, may be prominent or exaggerated, which may impart an irregular contour to the lu...

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...st Cancer Research Vol 5 No 5 Schnitt Table 1 Other names used to describe lesions within the category of flat epithelial atypia Description Reference Atypical cystic duct [2] Atypical cystic lobules =-=[3]-=- Atypical lobules type A (some examples) [4] Clinging carcinoma (monomorphic type) [5,6] Columnar alteration with prominent apical snouts and [7] secretions with atypia Columnar cell change with atypi...

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...traepithelial neoplasia of the flat monomorphic type [8] Hypersecretory hyperplasia with atypia (some examples) [9] Pretubular hyperplasia [10] Small ectatic ducts lined by atypical ductal cells with =-=[11]-=- apocrine snouts a Preferred diagnostic terms. some cases, may be prominent or exaggerated, which may impart an irregular contour to the luminal aspect of the acini. Flocculent secretions are often pr...

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...2 Outcome of patients with ‘clinging carcinoma’ (flat type, with low nuclear grade/monomorphic nuclei) European Organization for Research and Eusebi and colleagues [6] Treatment of Cancer Trial 10853 =-=[19]-=- Number of patients 25 59 Type of study Retrospective review of breast biopsies Prospective, randomized clinical trial originally considered benign Treatment Diagnostic biopsy; no attempt at excision ...

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...ncluded within this group are lesions that have recently been designated ‘flat epithelial atypia’ by the World Health Organization Working Group on the Pathology and Genetics of Tumours of the Breast =-=[1]-=-. Classification and pathologic features ‘Flat epithelial atypia’ is better considered a descriptive term that encompasses several different lesions, rather than a specific pathologic diagnosis per se...

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...toplasmic ratio is increased. Nucleoli are evident in some of the nuclei (hematoxylin & eosin, original magnification 40×).Available online http://breast-cancer-research.com/content/5/5/263 Figure 2 =-=[3,15,16]-=- and the progesterone receptor [13] in the majority of the cells. These cells also show strong cytoplasmic expression of the bcl-2 protein [15] and variable expression of cyclin D1 [13]. In most examp...

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...n a core needle biopsy specimen, subsequent excision shows a more advanced lesion in about one-third of cases. This is sufficiently frequent to recommend excision in such cases as a matter of routine =-=[20,21]-=-. The presence of flat epithelial atypia in an excisional biopsy specimen should prompt a careful search for areasAvailable online http://breast-cancer-research.com/content/5/5/263 with diagnostic fe...