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...e of the potential for distortions when normalizing the cerebellum to standard space (Diedrichsen et al., 2009), the cerebellum was normalized separately to a spatially unbiased atlas template (SUIT; =-=Diedrichsen, 2006-=-; Diedrichsen et al., 2009) also using ANTS. Similarly, the warp vectors were then applied to the functional images resulting in normalized whole-brain structural and functional images, and separate n...

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...ght side. In a whole brain analysis on the object task, we found a significant interaction effect in the right dorsal premotor cortex (45, 8, 37) and left cerebellum, namely lobule VI (−33, −61, −29, =-=Diedrichsen, 2006-=-). The BOLD signal changes extracted from the significant clusters are depicted in Fig. 2. Post-hoc t-tests revealed a significant difference between the right premotor BOLD activity during restraint ...

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... subject data to a common cerebral space leads to suboptimal alignment of cerebellar data, we utilized the spatially unbiased infratentorial template (SUIT) toolbox, version 2.5.2 (Diedrichsen, 2009; =-=Diedrichsen, 2006-=-) running on SPM8 (Friston, et al., 2007), to bring functional statistics maps of each subject into a common cerebellar space. Then, cerebellar group analysis consisted of voxel-wise, one-sample t-tes...

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...he inclusion of the superior cerebellum in this functional group is an artifact due to inconsistent spatial normalization across studies, as warping procedures typically behave poorly in this region (=-=Diedrichsen, 2006-=-). Thus, the connectivity with occipital regions may be driven by peaks that actually lie within the inferior temporal–occipital cortex. Nevertheless, this does not preclude the notion that the superi...

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...oimage.2012.11.041W. van der Zwaag et al. / NeuroImage 67 (2013) 354–362 355 Fig. 1. Anatomy of the cerebellum. A: a sagittal slice from the SUIT toolbox with the individual lobules shown in colour (=-=Diedrichsen, 2006-=-). The insert shows the position of the sagittal slice with a white line on a coronal slice. B: an equivalent slice of an anatomical from an example subject with the activation mask overlaid (f-test o...

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...essing � Using SPM5, fMRI data were realigned, smoothed with an 8 mm FWHM Gaussian kernel, detrended, coregistered with the twin’s 3D T1-weighted scan, and spatially normalised using the SUIT Toolbox =-=[1]-=-. � t-scores were extracted from 2>0-back contrast images generated at the single-subject level in each of 11,800 voxels comprising a cerebellar activation mask created from a group random effects ana...

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...left is –x, posterior is –y, inferior is –z) using a rigid body transformation performed in FLIRT (Jenkinson et al., 2002). The image origin was then set to the anterior commissure. The SUIT toolbox (=-=Diedrichsen, 2006-=-; Diedrichsen et al., 2009) was then used to automatically isolate the cerebellum and brainstem from the surrounding tissue. Image outputs from SUIT were manually edited using FSLView to remove the br...