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High prevalence of right ventricular involvement in endurance athletes with ventricular arrhythmias. Role of an electrophysiologic study in risk stratification.Eur

by Hein Heidbüchel , Jan Hoogsteen , Robert Fagard , L Vanhees , Hugo Ector , Rik Willems , Johan Van Lierde , M.D Hein Heidbüchel - Heart J , 2003
"... Background Electrocardiographic abnormalities and premature ventricular contractions are common in athletes and are generally benign. However, the specific outcome of high-level endurance athletes with frequent and complex ventricular arrhythmias is unclear. Also, information on the predictive accu ..."
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Background Electrocardiographic abnormalities and premature ventricular contractions are common in athletes and are generally benign. However, the specific outcome of high-level endurance athletes with frequent and complex ventricular arrhythmias is unclear. Also, information on the predictive accuracy of different investigations in this subgroup is unknown. Results We report on 46 high-level endurance athletes with ventricular arrhythmias (45 male; median age 31 years) followed-up for a median of 4.7 years. Eighty percent were cyclists. Hypertrophic cardiomyopathy or coronary abnormalities were present in ≤5%. Eighty percent of the arrhythmias had a left bundle branch morphology. Right ventricular (RV) arrhythmogenic involvement (based on a combination of multiple criteria) was manifest in 59% of the athletes, and suggestive in another 30%. Eighteen athletes developed a major arrhythmic event (sudden death in nine, all cyclists). They were significantly younger than those without event (median 23 years vs 38 years; P=0.01). Outcome could not be predicted by presenting symptoms, non-invasive arrhythmia evaluation or morphological findings at baseline. Only the induction of sustained ventricular tachycardia (VT) or ventricular fibrillation (VF) during invasive electrophysiological testing was significantly related to outcome (RR 3.4; P=0.02). Focal arrhythmias were associated with a better prognosis than those due to reentry (P=0.02) but the mechanism could be determined in only 22 (48%). Conclusions Complex ventricular arrhythmias do not necessarily represent a benign finding in endurance athletes. An electrophysiological study is indicated for risk evaluation, both by defining inducibility and identifying the arrhythmogenic mechanism. Endurance athletes with arrhythmias have a high prevalence of right ventricular structural and/or arrhythmic involvement. Endurance sports seems to be related to the development and/or progression of the underlying arrhythmogenic substrate.
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Connexin Defects Underlie Arrhythmogenic Right Ventricular Cardiomyopathy In a Novel Mouse Model

by Robert C. Lyon, Valeria Mezzano, Adam T. Wright, Emily Pfeiffer, Joyce Chuang, Allan Castaneda, Kunfu Ouyang, Li Cui, Riccardo Contu, Yusu Gu, Sylvia M. Evans, Jeffrey H. Omens, Kirk L. Peterson, Andrew D. Mcculloch, Farah Sheikh , 2013
"... #The authors wish it to be known that, in their opinion, the first two authors contributed equally to this work and should be regarded as joint first authors ..."
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#The authors wish it to be known that, in their opinion, the first two authors contributed equally to this work and should be regarded as joint first authors
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of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in Collaboration With the European Heart Rhythm Associat

by Martin Borggrefe, Arthur J. Moss, Alfred E. Buxton, Martin Fromer Md, Miguel A. Quinones
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Original article Ventricular arrhythmias in competitive athletes: risk stratification with T-wave alternans

by Giuseppe Inama, Claudio Pedrinazzi, Ornella Durin, Massimiliano Nanetti, Giorgio Donato, Rita Pizzi
"... ABSTRACT: Introduction: Aim of our study is to evaluate the role of TWA to stratify the risk of sudden cardiac death in athletes (Ath) with complex ventricular arrhythmias (VA), and to document a possible correlation between TWA and electrophysiological testing (EES) results. Methods: We studied 43 ..."
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ABSTRACT: Introduction: Aim of our study is to evaluate the role of TWA to stratify the risk of sudden cardiac death in athletes (Ath) with complex ventricular arrhythmias (VA), and to document a possible correlation between TWA and electrophysiological testing (EES) results. Methods: We studied 43 Ath with VA (31 M, mean age 34 ± 12 years). In all cases a cardiological evaluation was performed, including TWA and EES. The patients were evaluated during a followup

Collaboration With the European Heart Rhythm Association and the Heart Developed inArrhythmias and the Prevention of Sudden Cardiac Death): Committee to Develop Guidelines for Management of Patients With Ventricular European Society of Cardiology Committe

by Cynthia Tracy, J. Myerburg, Silvia G. Priori, Miguel A. Quinones, Dan M. Roden, Michael J. Silka, Martin Fromer, Gabriel Gregoratos, George Klein, Arthur J. Moss, Douglas P. Zipes, A. John Camm, Martin Borggrefe, Alfred E. Buxton , 2009
"... located on the World Wide Web at: The online version of this article, along with updated information and services, is ..."
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located on the World Wide Web at: The online version of this article, along with updated information and services, is
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Open Access Emergency Medicine 2010:2 99–114 Open Access Emergency Medicine Dovepress submit your manuscript | www.dovepress.com

by Emad F Aziz, Fahad Javed, Balaji Pratap, Eyal Herzog, Correspondence Eyal Herzog
"... R E v i E w open access to scientific and medical research Open Access Full Text Article DOI: 10.2147/OAEM.S6869 Strategies for the prevention and treatment of sudden cardiac death ..."
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R E v i E w open access to scientific and medical research Open Access Full Text Article DOI: 10.2147/OAEM.S6869 Strategies for the prevention and treatment of sudden cardiac death