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...tam antibiotics modestly enhances the rate of killing of pneumococci in vitro. Adding rifampin to beta-lactam antibiotics, vancomycin, or quinolones in vitro has often (7, 19, 21, 26), but not always =-=(1, 5, 24, 25)-=-, been associated with a reduction in bactericidal activity against other gram-positive bacteria. The use of such combinations in treating selected infections in experimental animals or infected human...

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...st gram-positive bacteria, including vancomycin-resistant enterococci (1, 5, 8, 10–12, 21). Rifampin has shown synergy with other drugs in animal models for the treatment for gram-positive infections =-=(2, 3, 7, 16, 17)-=-. In a synergy study with vancomycin-resistant E. faecium by Rand and Houck, it was suggested that, at subinhibitory daptomycin concentrations, daptomycin might bind to the bacterial cell, opening a c...

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...esistance. However, in contrast to S. aureus, the few published data on the efficacy of rifampin in combination with cephalosporins against MR strains of CoNS have not demonstrated antagonism in vivo =-=(3, 26, 27)-=-. The purpose of this study was to determine the activities in vitro and in vivo of cephalosporin-rifampin combinations by using a narrow-spectrum cephalosporin (cefazolin) or an aminothiazolyl cephal...