Results 1 - 10
of
11
Neutral effect of recombination on base composition in Drosophila
- in « Genet. Res. », number
"... Recombination is thought to have various evolutionary effects on genome evolution. In this study, we investigated the relationship between the base composition and recombination rate in the Drosophila melanogaster genome. Because of a current debate about the accuracy of the estimates of recombinati ..."
Abstract
-
Cited by 15 (1 self)
- Add to MetaCart
(Show Context)
Recombination is thought to have various evolutionary effects on genome evolution. In this study, we investigated the relationship between the base composition and recombination rate in the Drosophila melanogaster genome. Because of a current debate about the accuracy of the estimates of recombination rate in Drosophila, we used eight different measures of recombination rate from recent work. We confirmed that the G+C content of large introns and flanking regions is positively correlated with recombination rate, suggesting that recombination has a neutral effect on base composition in Drosophila. We also confirmed that this neutral effect of recombination is the main determinant of the correlation between synonymous codon usage bias and recombination rate in Drosophila. 1.
Standard and generalized McDonald–Kreitman test:
, 2008
"... a website to detect selection by comparing different classes of DNA sites ..."
Abstract
-
Cited by 6 (1 self)
- Add to MetaCart
a website to detect selection by comparing different classes of DNA sites
Leveraging Genomic Resources of Model Species for the Assessment of Diversity and Phylogeny in Wild and Domesticated Lentil
, 2011
"... Advances in comparative genomics have provided significant opportunities for analysis of genetic diversity in species with limited genomic resources, such as the genus Lens. Medicago truncatula expressed sequence tags (ESTs) were aligned with the Arabidopsis thaliana genome sequence to identify cons ..."
Abstract
-
Cited by 4 (0 self)
- Add to MetaCart
(Show Context)
Advances in comparative genomics have provided significant opportunities for analysis of genetic diversity in species with limited genomic resources, such as the genus Lens. Medicago truncatula expressed sequence tags (ESTs) were aligned with the Arabidopsis thaliana genome sequence to identify conserved exon sequences and splice sites in the ESTs. Conserved primers (CPs) based on M. truncatula EST sequences flanking one or more introns were then designed. A total of 22 % of the CPs produced polymerase chain reaction amplicons in lentil and were used to sequence amplicons in 175 wild and 133 domesticated lentil accessions. Analysis of the sequences confirmed that L. nigricans and L. ervoides are well-defined species at the DNA sequence level. Lens culinaris subsp. odemensis, L. culinaris subsp. tomentosus, and L. lamottei may constitute a single taxon pending verification with crossability experiments. Lens culinaris subsp. orientalis is the progenitor of domesticated lentil, L. culinaris subsp. culinaris (as proposed before), but a more specific area of origin can be suggested in southern Turkey. We were also able to detect the divergence, following domestication, of the domesticated gene pool into overlapping large-seeded (megasperma) and small-seeded (microsperma) groups. Lentil domestication led to a loss of genetic diversity of approximately 40%. The approach followed in this research has allowed us to rapidly exploit sequence information from
species group reveals complex histories and taxonomic
, 1997
"... this report we add a second locus, oskar, to our population genetic study of speciation. In D. melanogaster, the oskar gene is a maternal e#ect gene required for both posterior body patterning and germline formation in the early embryo, the D. irilis oskar homologue (also called irosk) is required f ..."
Abstract
- Add to MetaCart
this report we add a second locus, oskar, to our population genetic study of speciation. In D. melanogaster, the oskar gene is a maternal e#ect gene required for both posterior body patterning and germline formation in the early embryo, the D. irilis oskar homologue (also called irosk) is required for body patterning but may not be as important in pole cell formation (Webster et al., 1994). In D. melanogaster, oskar is located on the third chromosome (3R). Element 3R corresponds to chromosome 2 of the D. irilis phylad (Sturtevant & Novitski, 1941). A 2nd chromosome location of oskar in the D. irilis phylad is expected because of the high degree of conservation of chromosomal elements between D. melanogaster and D. irilis (Sturtevant & Novitski, 1941 ; Alexander, 1976). This conservation of linkage groups between D. melanogaster and D. irilis has also been confirmed for many individual loci (Whiting et al., 1989 ; Tonzetich et al., 1990 ; Neufeld et al., 1991) including period (Kress, 1993). In both D. a. americana and D. a. texana, chromosome 2 is fused with chromosome 3
mosquito
"... Blackwell Publishing Ltd.Intraspecific DNA variation in nuclear genes of the ..."
Abstract
- Add to MetaCart
(Show Context)
Blackwell Publishing Ltd.Intraspecific DNA variation in nuclear genes of the
Unusual pattern of single nucleotide polymorphism at the exuperantia2 locus of
, 2003
"... Drosophila pseudoobscura ..."
(Show Context)
Genetics of a-amanitin resistance in a natural population of Drosophila melanogaster
"... The genetic basis of variation in resistance to natural toxins is of interest for both ecological and evolutionary genetics. The wide variety of larval resources used by Drosophila, both within and between species, makes flies an excellent system for studying causes and consequences of selection res ..."
Abstract
- Add to MetaCart
The genetic basis of variation in resistance to natural toxins is of interest for both ecological and evolutionary genetics. The wide variety of larval resources used by Drosophila, both within and between species, makes flies an excellent system for studying causes and consequences of selection resulting from exposure to natural toxins associated with dierent resources. In this study we carry out a genetic analysis of a-amanitin resistance in a population sample of Drosophila melanogaster. Data from mapping crosses of chromosome III support a role for a naturally occurring polymor-phism in a multidrug resistance gene (Mdr65A) in a-amanitin resistance. However, there are no amino acid dierences between resistant and sensitive chromosomes at Mdr65A. Therefore, if Mdr65A mutants contribute to the dierence between a-amanitin-resistant and a-amanitin-sensitive third chromosome lines, the underlying cause is a gene regulatory mutation.
