Results 11 - 20 of 8,273

Animal models for muscular dystrophy show different patterns of sarcolemmal disruption

by Volker Straub, Jill A. Rafael, Jeffrey S. Chamberlain, Kevin P. Campbell - J. Cell , 1997
"... Abstract. Genetic defects in a number of components of the dystrophin–glycoprotein complex (DGC) lead to distinct forms of muscular dystrophy. However, little is known about how alterations in the DGC are manifested in the pathophysiology present in dystrophic muscle tissue. One hypothesis is that t ..."
Abstract - Cited by 116 (12 self) - Add to MetaCart
Abstract. Genetic defects in a number of components of the dystrophin–glycoprotein complex (DGC) lead to distinct forms of muscular dystrophy. However, little is known about how alterations in the DGC are manifested in the pathophysiology present in dystrophic muscle tissue. One hypothesis

Prokaryotic evolution in light of gene transfer

by J. Peter Gogarten, W. Ford Doolittle, Jeffrey G. Lawrence - Mol. Biol. Evol , 2002
"... Accumulating prokaryotic gene and genome sequences reveal that the exchange of genetic information through both homology-dependent recombination and horizontal (lateral) gene transfer (HGT) is far more important, in quantity and quality, than hitherto imagined. The traditional view, that prokaryotic ..."
Abstract - Cited by 115 (14 self) - Add to MetaCart
selection on genetic diversity, gene loss, and other chromosomal alterations as important players in adaptive evolution, gene exchange acts in concert with these processes to provide a rich explanatory paradigm—some of whose implications we explore here. In particular, we discuss (1) the role

genetic

by D K George, G A Ramm, L W Powell, L M Fletcher, N I Walker, L L Cowley, D H G Crawford
"... for altered hepatic matrix degradation in ..."
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for altered hepatic matrix degradation in

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

by Steven Estus, William J. Zaks, Robert S. Freeman, Maryann Gruda, Rodrigo Bravo, Eugene M. Johnson - J. Cell Biol , 1994
"... Abstract. We have examined the hypothesis that neuronal programmed cell death requires a genetic program; we used a model wherein rat sympathetic neurons maintained in vitro are deprived of NGF and subsequently undergo apoptosis. To evaluate gene expression potentially necessary for this process, we ..."
Abstract - Cited by 85 (7 self) - Add to MetaCart
Abstract. We have examined the hypothesis that neuronal programmed cell death requires a genetic program; we used a model wherein rat sympathetic neurons maintained in vitro are deprived of NGF and subsequently undergo apoptosis. To evaluate gene expression potentially necessary for this process

Methods for Competitive Co-evolution: Finding Opponents Worth Beating

by Christopher D. Rosin, Richard K. Belew - Proceedings of the Sixth International Conference on Genetic Algorithms , 1995
"... Co-evolution refers to the simultaneous evolution of two or more genetically distinct populations with coupled fitness landscapes. In this paper we consider "competitive co-evolution," in which the fitness of an individual in a "host" population is based on direct competition wit ..."
Abstract - Cited by 110 (2 self) - Add to MetaCart
Co-evolution refers to the simultaneous evolution of two or more genetically distinct populations with coupled fitness landscapes. In this paper we consider "competitive co-evolution," in which the fitness of an individual in a "host" population is based on direct competition

RNASEL and MIR146A SNP-SNP Interaction as a Susceptibility Factor for Non-Melanoma Skin Cancer

by Shohreh F. Farzan, Margaret R. Karagas, Brock C. Christensen, Zhongze Li, Jacquelyn K. Kuriger, Heather H. Nelson
"... Immunity and inflammatory pathways are important in the genesis of non-melanoma skin cancers (NMSC). Functional genetic variation in immune modulators has the potential to affect disease etiology. We investigated associations between common variants in two key regulators, MIR146A and RNASEL, and the ..."
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Immunity and inflammatory pathways are important in the genesis of non-melanoma skin cancers (NMSC). Functional genetic variation in immune modulators has the potential to affect disease etiology. We investigated associations between common variants in two key regulators, MIR146A and RNASEL

The altered evolutionary trajectories of gene duplicates

by Michael Lynch, Vaishali Katju - Trends Genet , 2004
"... Gene duplication is widely regarded as the predominant mechanism by which genes with new functions and associated phenotypic novelties arise. However, the mutational events and population-genetic mechanisms that lead to the short-term preservation of duplicate genes are not necessarily the same as t ..."
Abstract - Cited by 51 (1 self) - Add to MetaCart
Gene duplication is widely regarded as the predominant mechanism by which genes with new functions and associated phenotypic novelties arise. However, the mutational events and population-genetic mechanisms that lead to the short-term preservation of duplicate genes are not necessarily the same

Genetic alterations that inhibit in vivo pressureoverload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation

by MD; Giovanni Esposito , MD Antonio Rapacciuolo , ; Sathyamangla , PhD; V Naga Prasad , MD Hideyuki Takaoka , MD Steven A Thomas , PhD; Walter J Koch , MD Howard A Rockman
"... Background-A long-standing hypothesis has been that hypertrophy is compensatory and by normalizing wall stress acts to maintain normal cardiac function. Epidemiological data, however, have shown that cardiac hypertrophy is associated with increased mortality, thus casting doubt on the validity of t ..."
Abstract - Cited by 58 (3 self) - Add to MetaCart
of this hypothesis. Methods and Results-To determine whether cardiac hypertrophy is necessary to preserve cardiac function, we used 2 genetically altered mouse models that have an attenuated hypertrophic response to 8 weeks of pressure overload. End-systolic wall stress ( es ) obtained by sonomicrometry after 1 week

The origin of wealth: Evolution, complexity, and the radical remaking of economics

by Eric D. Beinhocker, Herbert Gintis , 2006
"... In this broad-ranging book, Eric Beinhocker defends a vision of the economy as a complex adaptive system. The theory that explains the operation of the economic system he calls Complexity Economics. The Origin of Wealth is a frontal attack on Neoclassical economic theory. Beinhocker recognizes the s ..."
Abstract - Cited by 102 (4 self) - Add to MetaCart
a workable analytical alternative to the Neoclassical model. He should not be dismissed, since the market economy is, in fact, a complex adaptive system, a fact that materially alters the analytical tools best deployed to model economic behavior. Indeed, some of the appropriate tools remain

Multiple Genetic Alterations in

by Human Carcinogenesis, Setsuo Hirohashi, Keiji Wakabayashil
"... Cancer development in man appeared to be a multistage process as suggested by epidemiological studies on commonly occurring gastric, colon, and breast cancers and also on human retrovirus-related leukemia, and by the finding by physicians and surgeons of precancerous lesions for many types of neopla ..."
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of neoplasias. In the last 10 years it has become evident that human cancers have multiple genetic alterations caused by point mutations, recombinations, amplifications, and/or deletions. The genes affected include both oncogenes and tumorsuppressor genes and genes that accelerate cell proliferation
Results 11 - 20 of 8,273