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Results 11 - 20
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200
Innodata Isogen White Paper HUNTING XML CMS ANTI-PATTERNS: FOUND IN THE WILD...
"... This paper discusses lesson learned from developing, evaluating, and integrating open standards into XML-based content management systems. The discussion focuses on common ideas and solutions that do not work, their flaws and consequences, and the realities of developing for and with such systems. X ..."
Abstract
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. XML content management systems are quickly becoming a cornerstone of real world business solutions. These systems integrate key XML specifications and standards with database technology and distributed Internet frameworks to provide advanced content management solutions. Many vendors target specific
Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model
- PLoS ONE
, 2011
"... Rett syndrome (RTT) is an autism spectrum developmental disorder caused by mutations in the X-linked methyl-CpG binding protein 2(MECP2) gene. Excellent RTT mouse models have been created to study the disease mechanisms, leading to many important findings with potential therapeutic implications. The ..."
Abstract
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Cited by 15 (1 self)
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. These include the identification of many MeCP2 target genes, better understanding of the neurobiological consequences of the loss- or mis-function of MeCP2, and drug testing in RTT mice and clinical trials in human RTT patients. However, because of potential differences in the underlying biology between humans
Bioengineering of a Nisin A-producing Lactococcus lactis to create isogenic strains producing the natural
"... Nisin is the prototypical example of the lantibiotic family of antimicrobial peptides and has been employed as a food preservative for over half a century. It has also attracted attention due to its potency against a number of multidrug-resistant clini-cal pathogens. Nisin A is the originally isolat ..."
Abstract
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series of different clinically sig-nificant pathogens establish differences in specific activities against selected targets. Nisin F was most impressive, being the most active, or one of the most
DOI 10.1007/s00122-007-0512-6ORIGINAL PAPER QTL mapping with near-isogenic lines in maize
"... maize was created using marker-assisted selection. Nineteen genomic regions, identiWed by restriction fragment length polymorphism loci and chosen to rep-resent portions of all ten maize chromosomes, were introgressed by backcrossing three generations from donor line Tx303 into the B73 genetic backg ..."
Abstract
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in targeted and back-ground introgressions. The average proportion of background introgression was 2.5 % (range 0–15%), signiWcantly lower than the expected value of 9.4 % for third backcross generation lines developed without marker-assisted selection. The NILs were grown in replicated Weld evaluations
In Vitro Effect of qnrA1, qnrB1, and qnrS1 Genes on Fluoroquinolone Activity against Isogenic Escherichia coli Isolates with Mutations
, 2010
"... This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant Ser83Leu substitutions in GyrA and/or Ser80Arg in ParC, on fluoroquinolone (FQ) resistance in isogenic Escherichia coli strains. The association of Ser83Leu substitution in Gy ..."
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This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant Ser83Leu substitutions in GyrA and/or Ser80Arg in ParC, on fluoroquinolone (FQ) resistance in isogenic Escherichia coli strains. The association of Ser83Leu substitution
Endogenous Targets of Transcriptional Gene Silencing
"... Transcriptional gene silencing (TGS) frequently inactivates foreign genes integrated into plant genomes but very likely also suppresses an unknown subset of chromosomal information. Accordingly, RNA analysis of mutants impaired in silencing should uncover endogenous targets of this epigenetic regula ..."
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Transcriptional gene silencing (TGS) frequently inactivates foreign genes integrated into plant genomes but very likely also suppresses an unknown subset of chromosomal information. Accordingly, RNA analysis of mutants impaired in silencing should uncover endogenous targets of this epigenetic
NLK Is a Novel Therapeutic Target for PTEN Deficient
, 2012
"... PTEN (Phosphatase and tensin homolog) is a tumour suppressor gene commonly defective in human cancer, and is thus a potentially important therapeutic target. Targeting tumour suppressor loss-of-function is possible by exploiting the genetic concept of synthetic lethality (SL). By combining the use o ..."
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PTEN (Phosphatase and tensin homolog) is a tumour suppressor gene commonly defective in human cancer, and is thus a potentially important therapeutic target. Targeting tumour suppressor loss-of-function is possible by exploiting the genetic concept of synthetic lethality (SL). By combining the use
Research Article Integrative Analysis of CRISPR/Cas9 Target Sites in
"... which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Recently, the clustered regularly interspaced short palindromic repeats (CRISPR) system has emerged as a powerful customizable artificial nuclease to facilitate precise genetic ..."
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genetic correction for tissue regeneration and isogenic disease modeling. However, previous studies reported substantial off-target activities of CRISPR system in human cells, and the enormous putative off-target sites are labor-intensive to be validated experimentally, thus motivating bioinformatics
Extending the GHS Weil descent attack
- Advances in Cryptology|EUROCRYPT 2002, LNCS 2332
, 2002
"... Abstract. In this paper we extend the Weil descent attack due to Gaudry, Hess and Smart (GHS) to a much larger class of elliptic curves. This extended attack applies to fields of composite degree over F2. The principle behind the extended attack is to use isogenies to find an elliptic curve for whic ..."
Abstract
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Cited by 44 (3 self)
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for which the GHS attack is effective. The discrete logarithm problem on the target curve can be transformed into a discrete logarithm problem on the isogenous curve. A further contribution of the paper is to give an improvement to an algorithm of Galbraith for constructing isogenies between elliptic curves
Therapeutics, Targets, and Chemical Biology Targeting the miR-221–222/PUMA/BAK/BAX PathwayAbrogatesDexamethasoneResistance in Multiple Myeloma
"... Despite recent therapeutic advances that have doubled the median survival time of patients with multiple myeloma, intra-tumor genetic heterogeneity contributes to disease progression and emergence of drug resistance. miRNAs are noncoding small RNAs that play important roles in the regulation of gene ..."
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of gene expres-sion and have been implicated in cancer progression and drug resistance. We investigated the role of the miR-221–222 family in dexamethasone-induced drug resistance in multiple myeloma using the isogenic cell lines MM1R and MM1S, which repre-sent models of resistance and sensitivity
Results 11 - 20
of
200
