Results 11 - 20 of 8,917

A new approach to decoding life: systems biology

by Trey Ideker, Timothy Galitski, Leroy Hood - Annu. Rev. Genomics Hum. Genet , 2001
"... Key Words biological information, discovery sciences, genome, proteome n Abstract Systems biology studies biological systems by systematically perturb-ing them (biologically, genetically, or chemically); monitoring the gene, protein, and informational pathway responses; integrating these data; and u ..."
Abstract - Cited by 231 (3 self) - Add to MetaCart
Key Words biological information, discovery sciences, genome, proteome n Abstract Systems biology studies biological systems by systematically perturb-ing them (biologically, genetically, or chemically); monitoring the gene, protein, and informational pathway responses; integrating these data

Diploid genome . . .

by Jong Hyun Kim, Michael S. Waterman, Lei M. Li , 2008
"... ..."
Abstract - Cited by 1 (0 self) - Add to MetaCart
Abstract not found

The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum

by Zbynek Bozdech, Manuel Llinás, Brian Lee Pulliam, Edith D. Wong, Jingchun Zhu, Joseph L. DeRisi , 2003
"... Plasmodium falciparum is the causative agent of the most burdensome form of human malaria, affecting 200–300 million individuals per year worldwide. The recently sequenced genome of P. falciparum revealed over 5,400 genes, of which 60 % encode proteins of unknown function. Insights into the biochemi ..."
Abstract - Cited by 213 (12 self) - Add to MetaCart
Plasmodium falciparum is the causative agent of the most burdensome form of human malaria, affecting 200–300 million individuals per year worldwide. The recently sequenced genome of P. falciparum revealed over 5,400 genes, of which 60 % encode proteins of unknown function. Insights

A probabilistic functional network of yeast genes

by Insuk Lee, Shailesh V. Date, Alex T. Adai, Edward M. Marcotte - Science , 2004
"... A conceptual framework for integrating diverse functional genomics data was developed by reinterpreting experiments to provide numerical likelihoods that genes are functionally linked. This allows direct comparison and integration of different classes of data. The resulting probabilistic gene networ ..."
Abstract - Cited by 207 (13 self) - Add to MetaCart
A conceptual framework for integrating diverse functional genomics data was developed by reinterpreting experiments to provide numerical likelihoods that genes are functionally linked. This allows direct comparison and integration of different classes of data. The resulting probabilistic gene

Methods for detecting associations with rare variants for common diseases: Application to analysis of sequence data.

by Bingshan Li , Suzanne M Leal - Am J Hum Genet , 2008
"... Although whole-genome association studies using tagSNPs are a powerful approach for detecting common variants, they are underpowered for detecting associations with rare variants. Recent studies have demonstrated that common diseases can be due to functional variants with a wide spectrum of allele ..."
Abstract - Cited by 201 (7 self) - Add to MetaCart
Although whole-genome association studies using tagSNPs are a powerful approach for detecting common variants, they are underpowered for detecting associations with rare variants. Recent studies have demonstrated that common diseases can be due to functional variants with a wide spectrum of allele

Consed: a graphical tool for sequence finishing

by David Gordon , Chris Abajian , Phil Green - Genome Res , 1998
"... Sequencing of large clones or small genomes is generally done by the shotgun approach Although complete automation of data processing in shotgun sequencing is clearly desirable and may be feasible in the near future, at present finishing still requires extensive human intervention. This is customa ..."
Abstract - Cited by 207 (0 self) - Add to MetaCart
Sequencing of large clones or small genomes is generally done by the shotgun approach Although complete automation of data processing in shotgun sequencing is clearly desirable and may be feasible in the near future, at present finishing still requires extensive human intervention

The sequence and de novo assembly of the giant panda genome.

by Ruiqiang Li , Wei Fan , Geng Tian , Hongmei Zhu , Lin He , Jing Cai , Quanfei Huang , Qingle Cai , Bo Li , Yinqi Bai , Zhihe Zhang , Yaping Zhang , Wen Wang , Jun Li , Fuwen Wei , Heng Li , Min Jian , Jianwen Li , Zhaolei Zhang , Rasmus Nielsen , Dawei Li , Wanjun Gu , Zhentao Yang , Zhaoling Xuan , Oliver A Ryder , Chi-Ching Frederick , Leung , Yan Zhou , Jianjun Cao , Xiao Sun , Yonggui Fu , Xiaodong Fang , Xiaosen Guo , Bo Wang , Rong Hou , Fujun Shen , Bo Mu , Peixiang Ni , Runmao Lin , Wubin Qian , Guodong Wang , Chang Yu , Wenhui Nie , Jinhuan Wang , Zhigang Wu , Huiqing Liang , Jiumeng Min , Qi Wu , Shifeng Cheng , Jue Ruan , Mingwei Wang , Zhongbin Shi , Ming Wen , Binghang Liu , Xiaoli Ren , Huisong Zheng , Dong Dong , Kathleen Cook , Gao Shan , Hao Zhang , Carolin Kosiol , Xueying Xie , Zuhong Lu , Hancheng Zheng , Yingrui Li , Cynthia C Steiner , Tommy Tsan , Yuk Lam , Siyuan Lin , Qinghui Zhang , Guoqing Li , Jing Tian , Timing Gong , Hongde Liu , Dejin Zhang , Lin Fang , Chen Ye , Juanbin Zhang , Wenbo Hu , Anlong Xu , Yuanyuan Ren , Guojie Zhang , Michael W Bruford , Qibin Li , Lijia Ma , Yiran Guo , Na An , Yujie Hu , Yang Zheng , Yongyong Shi , Zhiqiang Li , Qing Liu , Yanling Chen , Jing Zhao , Ning Qu , Shancen Zhao , Feng Tian , Xiaoling Wang , Haiyin Wang , Lizhi Xu , Xiao Liu , Tomas Vinar , Yajun Wang , Tak-Wah Lam , Siu-Ming Yiu , Shiping Liu , Hemin Zhang , Desheng Li , Yan Huang , Xia Wang , Guohua Yang , Zhi Jiang , Junyi Wang , Nan Qin , Li Li , Jingxiang Li , Lars Bolund , Karsten Kristiansen , Ka-Shu Gane , Wong , Maynard Olson , Xiuqing Zhang , Songgang Li , Huanming Yang , Jian Wang , Jun Wang - Nature , 2010
"... Using next-generation sequencing technology alone, we have successfully generated and assembled a draft sequence of the giant panda genome. The assembled contigs (2.25 gigabases (Gb)) cover approximately 94% of the whole genome, and the remaining gaps (0.05 Gb) seem to contain carnivore-specific re ..."
Abstract - Cited by 116 (4 self) - Add to MetaCart
composition. We also identified more than 2.7 million heterozygous single nucleotide polymorphisms in the diploid genome. Our data and analyses provide a foundation for promoting mammalian genetic research, and demonstrate the feasibility for using next-generation sequencing technologies for accurate, cost

STRING: a database of predicted functional associations between proteins

by Christian Von Mering, Martijn Huynen, Daniel Jaeggi, Steffen Schmidt, Peer Bork, Berend Snel - Nucleic Acids Res , 2003
"... Functional links between proteins can often be inferred from genomic associations between the genes that encode them: groups of genes that are required for the same function tend to show similar species coverage, are often located in close proximity on the genome (in prokaryotes), and tend to be inv ..."
Abstract - Cited by 180 (12 self) - Add to MetaCart
Functional links between proteins can often be inferred from genomic associations between the genes that encode them: groups of genes that are required for the same function tend to show similar species coverage, are often located in close proximity on the genome (in prokaryotes), and tend

K.L.: Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 19, 1655– 1664

by David H. Alexander, John Novembre, Kenneth Lange - Information Systems and Data Analysis , 1997
"... Population stratification has long been recognized as a confounding factor in genetic association studies. Estimated ancestries, derived from multi-locus genotype data, can be used as covariates to correct for population stratification. One popular technique for estimation of ancestry is the model-b ..."
Abstract - Cited by 135 (4 self) - Add to MetaCart
speed in comparison to structure. We present a new algorithm and a program, admixture, for model-based estimation of ancestry in unrelated individuals. admixture adopts the likelihood model embedded in structure. However, admixture runs considerably faster, solving problems in minutes that take

Dynamic remodeling of individual nucleosomes across a eukaryotic genome in response to transcriptional perturbation

by Sushma Shivaswamy, Akshay Bhinge, Yongjun Zhao, Steven Jones, Martin Hirst, Vishwanath R. Iyer - PLoS Biol , 2008
"... The eukaryotic genome is packaged as chromatin with nucleosomes comprising its basic structural unit, but the detailed structure of chromatin and its dynamic remodeling in terms of individual nucleosome positions has not been completely defined experimentally for any genome. We used ultra-high–throu ..."
Abstract - Cited by 131 (5 self) - Add to MetaCart
The eukaryotic genome is packaged as chromatin with nucleosomes comprising its basic structural unit, but the detailed structure of chromatin and its dynamic remodeling in terms of individual nucleosome positions has not been completely defined experimentally for any genome. We used ultra
Results 11 - 20 of 8,917