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Results 1 - 10
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2,048
p53 Inhibits DNA Replication In Vitro in a DNA-Binding- Dependent Manner
, 1995
"... p53 inhibits DNA replication in vitro in a ..."
Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by singlestranded DNA
- Mol.Cell. Biol
, 1997
"... Human replication protein A (RP-A) (also known as human single-stranded DNA binding protein, or HSSB) is a multisubunit complex involved in both DNA replication and repair. Potentially important to both these functions, it is also capable of complex formation with the tumor suppressor protein p53. H ..."
Abstract
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Cited by 12 (0 self)
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and replicative events. Increasing p53 concentrations can also overcome the inhibition by steady-state levels of RP-A, potentially mimicking cellular points of balance. Finally, it has been shown previously that p53 can itself be stimulated for site-specific DNA binding when complexed through the C terminus
Inhibition of HIV-1 replication by RNA interference of p53 expression
- J Leukoc Biol
, 2006
"... Abstract: p53 expression and activation have been associated to faster human immunodeficiency virus (HIV) disease progression, most probably by inducing CD4 T cell death but also through its cooperative effect in the control of viral gene tran-scription by viral regulatory proteins. Here, we show t ..."
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Cited by 3 (0 self)
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, which encode several mutations on the p53 DNA binding domain, death of HIV-1-induced syncytia was reduced in cocul-tures of HeLa P4-R5 MAGI with persistently in-fected HIV-1 cells. To our knowledge, this is the first demonstration of the effect of the loss of func-tion of p53 in HIV-1 replication, which
Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage.
- Mol. Cell.
, 2000
"... A regulatory network of proteins has been identified that participates in DNA damage checkpoint signaling. Central to this network is the ATM protein, the product of the gene mutated in the human disease ataxia-telangiectasia (Savitsky et al., 1995). Ataxia-telangiectasia (A-T) , 1996). In all or ..."
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Cited by 21 (2 self)
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to the daughter cells until repaired. In vertebrates, the molecular dissection of the G1 arFailure to monitor and to signal following DNA damage rest mechanism has mainly focused on studies of p53-is a hallmark of cancer cells (Hartwell and Kastan, 1994). dependent pathways. Responses mediated by p53 require
Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
- EMBO J
, 1999
"... We have demonstrated previously that the oncoprotein Mdm2 has a ubiquitin ligase activity for the tumor suppressor p53 protein. In the present study, we charac-terize this ubiquitin ligase activity of Mdm2. We first demonstrate the ubiquitination of several p53 point mutants and deletion mutants by ..."
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Cited by 86 (1 self)
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that DNA damage-induced phosphorylation stabilizes p53 by inhibiting its ubiquit-ination by Mdm2. We further investigated whether the tumor suppressor p19ARF affects the ubiquitin ligase activity of Mdm2 for p53. The activity of p19ARF-bound Mdm2 was found to be lower than that of free Mdm2, suggesting
p53 Protects renal inner medullary cells from hypertonic stress by restricting DNA replication
- Am J Physiol Renal Physiol 281: F522–F530
, 2001
"... Dmitrieva, Natalia, Luis Michea, and Maurice Burg. p53 Protects renal inner medullary cells from hypertonic stress by restricting DNA replication. Am J Physiol Renal Physiol 281: F522-F530, 2001.-We previously found that p53 upregulation by hypertonicity protected renal inner medullary collecting d ..."
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Cited by 6 (0 self)
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duct (mIMCD3) cells from apoptosis. The purpose of the present study was to investigate the mechanism by which p53 protects the cells. We now find that hypertonicity (NaCl added to a total of 500 mosmol) inhibits DNA replication and delays G 1-S transition as concluded from analysis of cell cycle
Inhibition of DNA replication fork progression and
, 2007
"... mutagenic potential of 1, N 6-ethenoadenine and 8-oxoguanine in human cell extracts ..."
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mutagenic potential of 1, N 6-ethenoadenine and 8-oxoguanine in human cell extracts
Anti-cancer DNA Intercalators cause p53 Dependent
"... Many anti-cancer drugs, such doxorubicin (DXR), intercalate into nuclear DNA of cancer cells thereby inhibiting their growth. However, it is not well understood how such drugs interact with mitochondrial DNA (mtDNA). Using cell and molecular studies of cultured cells we show that DXR and other DNA i ..."
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increased by p53 or ATM inhibition, indicating a link between nucleoid dynamics and the genomic DNA damage response. Collectively, our results show that DNA intercalators can trigger a common mitochondrial response, which likely contributes to the marked clinical toxicity associated with these drugs.
ATR Is Not Required for p53 Activation but Synergizes with p53 in the Replication Checkpoint*
, 2001
"... ATR (ataxia telangiectasia and Rad-3-related) is a pro-tein kinase required for survival after DNA damage. A critical role for ATR has been hypothesized to be the regulation of p53 and other cell cycle checkpoints. ATR has been shown to phosphorylate p53 at Ser15, and this damage-induced phosphoryla ..."
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ATR (ataxia telangiectasia and Rad-3-related) is a pro-tein kinase required for survival after DNA damage. A critical role for ATR has been hypothesized to be the regulation of p53 and other cell cycle checkpoints. ATR has been shown to phosphorylate p53 at Ser15, and this damage
Hemicatenanes form upon inhibition of DNA replication
- Nucl Acid Res
, 2000
"... Plasmid DNA incubated in interphase Xenopus egg extracts is normally assembled into chromatin and then into synthetic nuclei which undergo one round of regulated replication. During a study of restriction endonuclease cut plasmid replication intermediates (RIs) by the Brewer–Fangman 2D gel electroph ..."
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Cited by 6 (0 self)
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electrophoresis technique, we have observed the formation of a strong spike of X-shaped DNA molecules in extracts that otherwise yield very little or no RIs. Formation of these joint molecules is also efficiently induced in replication-competent extracts upon inhibition of replication fork progression
Results 1 - 10
of
2,048
