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Effects of Single Injection of Local Anesthetic Agents on Intervertebral Disc Degeneration: Ex Vivo and Long-Term In Vivo Experimental Study

by Koji Iwasaki, Hideki Sudo, Katsuhisa Yamada, Hideaki Higashi, Takashi Ohnishi, Takeru Tsujimoto, Norimasa Iwasaki
"... Background: Analgesic discography (discoblock) can be used to diagnose or treat discogenic low back pain by injecting a small amount of local anesthetics. However, recent in vitro studies have revealed cytotoxic effects of local anesthetics on intervertebral disc (IVD) cells. Here we aimed to invest ..."
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% lidocaine or 0.5 % bupivacaine). Nucleus pulposus (NP) cell death was measured using confocal microscopy. Histological and TUNEL assays were performed. For in vivo study, each local anesthetic was injected into rabbit lumbar IVDs under a fluoroscope. Six or 12 months after the injection, each IVD

Research Article Insulin-Loaded Nanoparticles Based on N-Trimethyl Chitosan: In Vitro (Caco-2 Model) and Ex Vivo (Excised Rat Jejunum, Duodenum, and Ileum) Evaluation of Penetration Enhancement Properties

by unknown authors , 2010
"... Abstract. The aim of this paper was to evaluate the penetration enhancement properties of nanoparticles (NP) based on N-trimethyl chitosan (TMC 35 % quaternization degree) loaded with insulin. The permeation performances of TMC NP were compared with those of chitosan (CS) NP and also with TMC and CS ..."
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and CS solutions. To estimate the mechanism of penetration enhancement, two different approaches have been taken into account: an in vitro study (Caco-2 cells) and an ex vivo study (excised rat duodenum, jejunum, and ileum). Insulin-loaded CS and TMC NP had dimensions of about 250 nm and had high yield

The nitrogen and phosphorus dependence of algal biomass in lakes: an empirical and theoretical analysis

by Val H. Smith - Limnol. Oceanogr , 1982
"... An analysis of mean growing season concentrations of chlorophyll, total phosphorus (TP), and total nitrogen (TN) in 228 north latitude lakes confirms previous observations that chlo-rophyll yield is dependent both on the phosphorus concentration and on the TN:TP ratio. Of two modified chlorophyll mo ..."
Abstract - Cited by 62 (5 self) - Add to MetaCart
models which depend explicitly on both nitrogen and phosphorus developed and tested, one, a multiple regression model, appears to greatly reduce the error of chlorophyll prediction in lakes. A theoretical framework is presented which provides an explanation for the observed effects of N:P ratios

Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion, and nanoprecipitation

by Sergio Galindo-rodriguez, Hatem Fessi, Eric Doelker
"... Purpose. The aim of this work was to relate the physicochemical properties of the aqueous and organic phases used for nanoparticle (NP) preparation to the formation of NP produced by salting-out, emulsification-diffusion, and nanoprecipitation. Methods. Methacrylic acid copolymer and poly(vinyl alco ..."
Abstract - Cited by 17 (0 self) - Add to MetaCart
by their viscosity and surface tension. NP characteristics such as particle mean size, residual surfactant, sus-pendability in water after freeze-drying, and morphology were ex-plained in terms of these properties. For nanoprecipitation, NP for-mation was analyzed considering the diffusion-stranding phenom

ON THE FUNCTIONAL CLT FOR PARTIAL SUMS OF TRUNCATED BOUNDED FROM BELOW RANDOM VARIABLES

by Vladimir Pozdnyakov
"... Abstract. Let {X,Xi}i≥1 be i.i.d. bounded from below continuous random variables, E|X | < ∞, EX2 = ∞, and {bn}n≥1 be a sequence of increasing positive numbers. When X belongs to the Feller class and bn is such that nP X> bn ..."
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Abstract. Let {X,Xi}i≥1 be i.i.d. bounded from below continuous random variables, E|X | < ∞, EX2 = ∞, and {bn}n≥1 be a sequence of increasing positive numbers. When X belongs to the Feller class and bn is such that nP X> bn

Individual and synergistic effects of rabbit granulocyte proteins

by Ofer Levy, Chean Eng Ooi, Jerrold Weiss, Robert Lehrer, Peter Elsbach - J. Clin. Invest. 94:672 , 1994
"... Affinity purification of crude acid extracts of rabbit poly-morphonuclear leukocytes using Escherichia coli (J5) as ad-sorbent yields the bactericidal/permeability-increasing pro-tein (BPI), two 15-kD species (pl5s), and the two most potent (cationic) defensin species (neutrophil peptides [NP]-1 and ..."
Abstract - Cited by 15 (5 self) - Add to MetaCart
Affinity purification of crude acid extracts of rabbit poly-morphonuclear leukocytes using Escherichia coli (J5) as ad-sorbent yields the bactericidal/permeability-increasing pro-tein (BPI), two 15-kD species (pl5s), and the two most potent (cationic) defensin species (neutrophil peptides [NP]-1

On Two Techniques of Combining Branching and Treewidth

by Fedor V. Fomin, Serge Gaspers, Saket Saurabh, Alexey A. Stepanov - ALGORITHMICA (2009) 54: 181–207 , 2009
"... Branch & Reduce and dynamic programming on graphs of bounded treewidth are among the most common and powerful techniques used in the design of moderately exponential time exact algorithms for NP hard problems. In this pa-per we discuss the efficiency of simple algorithms based on combinations o ..."
Abstract - Cited by 19 (3 self) - Add to MetaCart
algorithms. We give several ex-amples of possible combinations of branching and programming which provide the fastest known algorithms for a number of NP hard problems. All our algorithms re-quire non-trivial balancing of these two techniques. In the first approach the algorithm either performs fast

WEIGHTED SHARING AND UNIQUENESS OF MEROMORPHIC FUNCTIONS

by Harina P. Waghamore, Tanuja Adaviswamy
"... Abstract. In this paper, we study with a weighted sharing method the uniqueness prob-lem of [ f nP ( f)](k) and [gnP (g)](k) sharing one value and obtain some results which ex-tend and improve the results due to Hong-Yan Xu and Ting-Bin Cao. 1. ..."
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Abstract. In this paper, we study with a weighted sharing method the uniqueness prob-lem of [ f nP ( f)](k) and [gnP (g)](k) sharing one value and obtain some results which ex-tend and improve the results due to Hong-Yan Xu and Ting-Bin Cao. 1.

�q ∈ (f(x) − p(x))q(x)> 0, ∀x ∈ A.

by unknown authors
"... ∈ C[a,b]�X �����n���p ∗�p ∗ − f‖X = min ‖p − f‖X. p∈Pn 1. L∞ � inf max p∈Pn a≤x≤b |p(x) − f(x)|. e(x): = p ∗ (x) − f(x), Pn� f ∈ C[a,b]�Pn ..."
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∈ C[a,b]�X �����n���p ∗�p ∗ − f‖X = min ‖p − f‖X. p∈Pn 1. L∞ � inf max p∈Pn a≤x≤b |p(x) − f(x)|. e(x): = p ∗ (x) − f(x), Pn� f ∈ C[a,b]�Pn

Automatic Reductions from PH into STRIPS or How to Generate Short Problems with Very Long Solutions

by Aldo Porco, Alejandro Machado, Blai Bonet
"... Recently, it has been shown how to automatically translate any problem in NP, expressed in the language of second-order logic, into a STRIPS planning problem. In this work, we ex-tend such translations by considering decision problems in the polynomial-time hierarchy (PH) and not just NP. Since deci ..."
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Recently, it has been shown how to automatically translate any problem in NP, expressed in the language of second-order logic, into a STRIPS planning problem. In this work, we ex-tend such translations by considering decision problems in the polynomial-time hierarchy (PH) and not just NP. Since
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