The previous articles in this special section make the case for the importance of evaluating the clinical significance of therapeutic change, present key measures and innovative ways in which they are applied, and more generally provide important guidelines for evaluating therapeutic change

A nurse practitioner at the worksite can provide valuable health care services to enhance the health status of employees; in addition such an initiative also enhances the overall effectiveness of clinic-based health care services.

-theoretic technology. PURPOSE: Clinical guidelines, based on clinical trials, do not address three important uncer-tainties: (1) uncertain relevance of tested populations to the individual patient, (2) the patient’s uncertain preferences among possible outcomes, and (3) uncertain subjective and financial costs

Copyright © 2015 Timothy Bowen et al.This is an open access article distributed under theCreative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hyaluronan (HA) is a ubiquitous extracellular matrix glycosaminoglycan composed of repeated disaccharide units of alternating D-glucuronic acid and D-N-acetylglucosamine residues linked via alternating

after primary cytoreductive surgery in ovarian cancer To the editor: The current study is meaningful in that the de-cline in serum CA125 levels after primary cytoreductive sur-gery may affect progressionfree survival (PFS) in patients with epithelial ovarian cancer (EOC). Moreover, similar stud-ies have also shown that the serum CA125 level may be a prognostic factor for the prediction of survival in patients with EOC although the time to evaluate serum CA125 levels was different.13 However, some questions should be resolved for under-standing the role of serum CA125 levels in EOC. Firstly, his-tological type of EOC may affect serum CA125 levels. Especially, serum CA125 levels are known to be lower in clear cell or mucinous carcinoma than in serous adeno-

frequency and clinical significance of detection of DNA of cytomegalovirus (CMV), Epstein-Barr virus

that the result could have occurred by chance and does not prove the truth of the study. 3. Define what a hazard ratio expresses. This article is available for continuing medical education credit at CME.TheOncologist.com.CME Modern clinical trials provide the evidence for most ther-apeutic advances

Background: Spirochaetes are well known causative agents of diarrhoea in veterinary medicine. However, there is no agreement as to whether or not they have any clinical significance in humans. Aims: To assess the symptoms associated with intestinal spirochaetosis, their response to treatment

differences between home and clinic systolic blood pressure readings in patients with hypertension

, the clinical significance of MBs in SVaD has not been studied yet. The objective of this study was to examine the relationships between the number of MBs and the cognitive deficits in SVaD.