Estimation of Probe Cell Locations in High-density Synthetic-oligonucleotide DNA Microarrays
Download:
by Harry Zuzan, Carrie Blanchette, Holly Dressman, Erich Huang, Seiichi Ishida, Jeffrey R. Marks, Joseph R. Nevins, Rainer Spang Mike West
http://ftp.isds.duke.edu/WorkingPapers/02-05.pdf
Add To MetaCart
Abstract:
The source of a spatial contribution to the coefficient of variation in Affymetrix GeneChip r ○ probe cell summaries was determined to be caused by a misalignment of probe cell locations in the hybridisation image. Described, is an algorithm that corrects for misalignment resulting in improved allocation of pixel intensities to probe cells and a substantial reduction in the variance of pixel intensities attributed to individual probe cells.
Citations
| 94 | Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection – Li, Wong - 2001 |
| 78 | High density synthetic oligonucleotide arrays – Lipshutz, Fodor, et al. - 1999 |
| 22 | et al. Expression monitoring by hybridization to high-density oligonucleotide arrays – Lockhart - 1996 |
| 16 | Analyzing high-density oligonucleotide gene expression array data – Schadt, Li, et al. - 2001 |
| 1 | A hierarchical feature based deformation model applied to 4D cardiac SPECT data – Laading, McCulloch, et al. - 1999 |
