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Abstract: . We propose a mapping from digital logic circuits into genetic regulatory networks with the following property: the chemical activity of such a genetic network in vivo implements the computation specified by the corresponding digital circuit. Logic signals are represented by the synthesis rates of cytoplasmic DNA binding proteins. Gates consist of structural genes for output proteins, fused to promoter/operator regions that are regulated by input proteins. The modular approach for building... (Update)
Context of citations to this paper: More
.... Figure 7 shows the inverter s dynamic behavior derived from numerical simulation of the actual chemical kinetics for suitable proteins (see [25]) Given the ability to implement inverters in cells, arbitrary logic gates can then be realized as combinations of inverters. For...
...of translation. This translation rate is included in a biochemical reaction for modeling and simulating the inverter using BioSPICE[10, 9]. For a given input mRNA level, a reduction in the translation rate yields a lower input protein level, which pushes the entire transfer...
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BibTeX entry: (Update)
Ron Weiss et. al. Toward in vivo digital circuits. In Proceedings of DIMACS Workshop on Evolution as Computation, 1999. http://citeseer.ist.psu.edu/weiss99toward.html More
@misc{ weiss99toward,
author = "R. Weiss",
title = "Toward in vivo digital circuits",
text = "Ron Weiss et. al. Toward in vivo digital circuits. In Proceedings of DIMACS
Workshop on Evolution as Computation, 1999.",
year = "1999",
url = "citeseer.ist.psu.edu/weiss99toward.html" }
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