Pathogenesis of Schizophrenic Delusions and Hallucinations: A Neural Model

Pathogenesis of Schizophrenic Delusions and Hallucinations: A Neural Model (1995)

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by Eytan Ruppin , James A. Reggia , David Horn , David Horn Phd

Venue:	Schizophrenia Bulletin
Citations:	3 - 0 self

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Datum	Value	Source
TITLE	Pathogenesis of Schizophrenic Delusions and Hallucinations: A Neural Model	user correction - Legacy Corrections
AUTHOR NAME	Eytan Ruppin	user correction - Legacy Corrections
AUTHOR NAME	James A. Reggia	user correction - Legacy Corrections
AUTHOR AFFIL	y; Department of Neurology; University of Maryland Hospital	user correction - Legacy Corrections
AUTHOR ADDR	22 South Greene St.; Baltimore, MD 21201	user correction - Legacy Corrections
AUTHOR NAME	David Horn	user correction - Legacy Corrections
AUTHOR NAME	David Horn Phd	user correction - Legacy Corrections
AUTHOR AFFIL	School of Physics; Raymond and Beverly Sackler Faculty of Exact Sciences	user correction - Legacy Corrections
AUTHOR ADDR	Tel Aviv University, Tel Aviv 69978, Israel	user correction - Legacy Corrections
ABSTRACT	We implement and study a computational model of Stevens' [1992] theory of the pathogenesis of schizophrenia. This theory hypothesizes that the onset of schizophrenia is associated with reactive synaptic regeneration occurring in brain regions receiving degenerating temporal lobe projections. Concentrating on one such area, the frontal cortex, we model a frontal module as an associative memory neural network whose input synapses represent incoming temporal projections. Modeling Stevens' hypothesized pathological synaptic changes in this framework results in adverse side effects reminiscent of hallucinations and delusions seen in schizophrenia: spontaneous, stimulusindependent retrieval of stored memories focused on just a few of the stored patterns. These could account for the occurrence of schizophrenic delusions and hallucinations without any apparent external trigger, and for their tendency to concentrate on a few central cognitive and perceptual themes. The model explains why schizo...	user correction - Legacy Corrections
YEAR	1995	user correction - Legacy Corrections
VENUE	Schizophrenia Bulletin	INFERENCE
VENUE TYPE	JOURNAL	INFERENCE
PAGES	105--123	INFERENCE
VOLUME	22	INFERENCE
CITATIONS	57 found	ParsCit 1.0