Bioinformatic Principles Underlying the Information Content of Transcription Factor Binding Sites (2003)
| Venue: | Journal of Theoretical Biology |
| Citations: | 6 - 3 self |
BibTeX
@ARTICLE{Kim03bioinformaticprinciples,
author = {Jan T. Kim and Thomas Martinetz and Daniel Polani},
title = {Bioinformatic Principles Underlying the Information Content of Transcription Factor Binding Sites},
journal = {Journal of Theoretical Biology},
year = {2003},
volume = {220},
pages = {2003}
}
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Abstract
Empirically, it has been observed in several cases that the information content of transcription factor binding site sequences (465798-:79;<97 ) approximately equals the information content of binding site positions (4>=@? 7A8-:79;<CB ). A general framework for formal models of transcription factors and binding sites is developed to address this issue. Measures for information content in transcription factor binding sites are revisited and theoretic analyses are compared on this basis. These analyses do not lead to consistent results. A comparative review reveals that these inconsistent approaches do not include a transcription factor state space.
