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@MISC{_researcharticle,
author = {},
title = {RESEARCH ARTICLE Different duration strategi d},
year = {}
}
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Abstract
Full list of author information is available at the end of the articleThe principles of antibiotic prophylaxis are based on (1) the choice of the antimicrobial agent; (2) the timing of the first administered dose, and (3) the duration of the prophylactic regimen [1]. Concerning the choice of the antimicrobial agent second-generation cephalosporins in particular have several advantages over other antibiotic choices. They provide broad-spectrum coverage target-ing both gram-positive and gram-negative organisms, good safety profile with minimal side effects, and can be tolerated by penicillin allergic patients. However, a dis-advantage of cephalosporins is a well-established associ-ation with Clostridium difficile infection [2]. Several studies described that there is a trend towards prescrib-ing more second generation cephalosporins [3,4]. Also, the German Paul-Ehrlich-Gesellschaft e.V. (PEG) recom-mends a second-generation cephalosporin as antibiotic prophylaxis in patients undergoing cardiac surgery [5]. Concerning the duration of the prophylactic regimen the data of the international guidelines and recommen-
Keyphrases
research article different duration strategi prophylactic regimen antibiotic prophylaxis second generation cephalosporin second-generation cephalosporin full list antibiotic choice well-established associ-ation articlethe principle antimicrobial agent patient undergoing cardiac surgery international guideline author information german paul-ehrlich-gesellschaft several advantage clostridium difficile infection gram-negative organism penicillin allergic patient broad-spectrum coverage good safety profile several study minimal side effect antimicrobial agent second-generation cephalosporin
