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How To Learn from Patients: Fuller Albright's Exploration of Adrenal Function
BibTeX
@MISC{Schwartz_howto,
author = {Theodore B. Schwartz},
title = {How To Learn from Patients: Fuller Albright's Exploration of Adrenal Function},
year = {}
}
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Abstract
the preeminent clinical and investigative endocrinolo-gist of his day by many of his contemporaries, but his many achievements are all but unknown to the present generation of physicians. This article describes how he used his clinical knowledge and a few tools—the mea-surement of urinary 17-ketosteroid excretion and the administration of methyltestosterone—to elucidate the major hormonal functions of the adrenal cortex and to clarify the pathophysiology of the Cushing syndrome. In addition, in a tour de force of clinical reasoning, he predicted, 5 years before the event, the discovery of a hormone that would reverse the endocrinologic abnor-malities of congenital adrenal hyperplasia. Fittingly, he and pioneer pediatric endocrinologist Lawson Wilkins were the first to treat this disease successfully with cortisone. Ann Intern Med. 1995;123:225-229. The charm of Dr. Albright's presentations is that he not only presents some of the facts that they have discovered, but he also tells us how they may be interpreted.
Keyphrases
adrenal function fuller albright major hormonal function clinical knowledge congenital adrenal hyperplasia clinical reasoning adrenal cortex present generation ann intern med many achievement investigative endocrinolo-gist urinary 17-ketosteroid excretion cushing syndrome endocrinologic abnor-malities pediatric endocrinologist lawson wilkins
