DMCA
Neural mechanisms for response selection: comparing selection of responses and items from working memory (2007)
| Venue: | Neuroimage |
| Citations: | 6 - 0 self |
BibTeX
@ARTICLE{Hester07neuralmechanisms,
author = {Robert Hester and C Michael W. Cole and Hugh Garavanb},
title = {Neural mechanisms for response selection: comparing selection of responses and items from working memory},
journal = {Neuroimage},
year = {2007},
pages = {446--454}
}
Share
 |
 |
 |
 |
||
OpenURL
Abstract
Recent functional imaging studies of working memory (WM) have suggested a relationship between the requirement for response selection and activity in dorsolateral prefrontal (DLPFC) and parietal regions. Although a number of WM operations are likely to occur during response selection, the current study was particularly interested in the contribution of this neural network to WM-based response selection when compared to the selection of an item from a list being maintained in memory, during a verbal learning task. The design manipulated stimulus–response mappings so that selecting an item from memory was not always accompanied with selecting a motor response. Functional activation during selection supported previous findings of fronto-parietal involvement, although in contrast to previous findings left, rather than right, DLPFC activity was significantly more active for selecting a memory-guided motor response, when compared to selecting an item currently maintained in memory or executing a memory-guided response. Our results contribute to the debate over the role of fronto-parietal activity during WM tasks, suggesting that this activity appears particularly related to response selection, potentially supporting the hypothesized role of prefrontal activity in biasing attention toward task-relevant material in more posterior regions. © 2006 Elsevier Inc. All rights reserved.
Keyphrases
response selection neural mechanism previous finding memory-guided response functional activation hypothesized role posterior region neural network dorsolateral prefrontal dlpfc activity task-relevant material fronto-parietal activity elsevier inc wm operation recent functional imaging study current study wm-based response selection fronto-parietal involvement memory-guided motor response verbal learning task motor response stimulus response mapping wm task parietal region prefrontal activity
