Reference materials and reference methods in clinical chemistry (1979)
| Venue: | J Clin Chem Clin Biochem |
| Citations: | 6 - 1 self |
BibTeX
@ARTICLE{Stamm79referencematerials,
author = {Byd Stamm},
title = {Reference materials and reference methods in clinical chemistry},
journal = {J Clin Chem Clin Biochem},
year = {1979}
}
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Abstract
Summary: In clinical chemistry today there are often several different methods and instruments in use for the analysis of a particular constituent. When these different methods and instruments are used for careful analysis of the same control specimen, as in assigned value determinations, the assigned values obtained may be significantly different, and these differences may be of clinical importance. In order to determine the reasons for such differ-ences, reference systems or reference points are needed. The reference systems for calibration (calibration materials, standard reference materials) and control (control materials), where the matrices of these different materials must have quite different characteristics, are referred to jointly as reference materials. In order to compare methods, reference methods are needed with known, high reliability. Because of the amount of specimen material needed, the time needed for analysis and the facilities required, reference methods are not suitable for routine analysis. Ideally, standard reference materials are developed first, followed by a definitive method, which is then used to evaluate a candidate reference method. This is currently the case for only a small number of the constituents analyzed in the clinical chemistry laboratory. In this paper the characteristics of the different kinds of reference materials and of reference methods are described. The differences in terminological usage found in the literature are discussed. Limitations of knowledge and technique may necessitate certain compromises, with respect to the ideal character-istics of reference materials and reference methods. Possible compromises are discussed, and the various sources
Keyphrases
reference method reference material clinical chemistry standard reference material reference system clinical chemistry today high reliability calibration material assigned value determination different material control material control specimen different method specimen material different kind various source particular constituent certain compromise definitive method candidate reference method ideal character-istics clinical chemistry laboratory terminological usage small number assigned value several different method routine analysis different characteristic careful analysis clinical importance reference point possible compromise
