BibTeX
@MISC{Gu_|researchfocus,
author = {Xun Gu},
title = {|Research Focus Evolution of duplicate genes versus genetic robustness},
year = {}
}
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Abstract
There are two proposed mechanisms for the emergence of gene network robustness: (1) ‘genetic buffering ’ from redundant gene networks (i.e. alternative metabolic or regulatory or signal pathways), and (2) functional com-plementation from duplicate genes. Their relative sig-nificance is a subject to debate, but recent studies in functional genomics provide some interesting insights. In particular, experiments in yeast using whole-genome libraries of single-gene-deletion mutants and worm whole-genome RNAi show that both mechanisms are important for the genetic robustness. Yet, many questions remain. Molecular biologists know that mutations without a phenotype are not exceptional. Yet in many ‘wet ’ labora-tories, natural or laboratory-generated null mutations are
Keyphrases
duplicate gene genetic robustness research focus evolution interesting insight recent study genetic buffering functional com-plementation functional genomics single-gene-deletion mutant many wet labora-tories whole-genome library gene network robustness alternative metabolic laboratory-generated null mutation redundant gene network proposed mechanism relative sig-nificance molecular biologist whole-genome rnai show signal pathway many question
