DMCA
DAMPs and inflammatory processes: the role of redox in the different outcomes (2009)
| Venue: | Journal of Leukocyte Biology |
| Citations: | 4 - 0 self |
BibTeX
@ARTICLE{Carta09dampsand,
author = {Sonia Carta and Patrizia Castellani and Laura Delfino and Sara Tassi and Anna Rubartelli},
title = {DAMPs and inflammatory processes: the role of redox in the different outcomes},
journal = {Journal of Leukocyte Biology},
year = {2009},
pages = {549--555}
}
Share
 |
 |
 |
 |
||
OpenURL
Abstract
Inflammation is deeply entangled with redox modula-tion. Triggering of PRRs on inflammatory cells induces ROS generation. As a consequence, activated cells mount antioxidant responses to counteract the possi-ble harmful effects of oxidation. Therefore, when repair is completed, homeostasis is restored. Here, we de-scribe some recent results showing that an exuberant antioxidant response to pro-oxidant inflammatory stimuli modifies not only the intra- but also the extra-cellular redox and contributes to the outcome of the inflammatory process. In particular, the role of redox modulation in IL-1 secretion, in B lymphocyte differ-entiation to plasma cells, and in tumor progression will be discussed, and the potential consequences of extracellular redox alterations on DAMP activity will be considered. J. Leukoc. Biol. 86: 000–000; 2009.
Keyphrases
inflammatory process different outcome activated cell redox modulation inflammatory cell induces ro generation exuberant antioxidant response redox modula-tion extra-cellular redox il-1 secretion damp activity pro-oxidant inflammatory stimulus possi-ble harmful effect antioxidant response potential consequence extracellular redox alteration tumor progression lymphocyte differ-entiation recent result
