DMCA
Synthesis and Screening of a Small Library of Proline-Based Biodendrimers for Use as Delivery Agents
BibTeX
@MISC{Shen_synthesisand,
author = {Hong Shen and Ernest Giralt and Fernando Albericio and Mark William Saltzman and Miriam Royo},
title = {Synthesis and Screening of a Small Library of Proline-Based Biodendrimers for Use as Delivery Agents},
year = {}
}
Share
 |
 |
 |
 |
||
OpenURL
Abstract
Abstract: A small library of defined peptide dendrimers based on polyproline sequences was designed to demonstrate the feasibility of generating a new type of polymeric agent for therapeutic use. Structural modifications to dendrimer surfaces further enriched the diversity of the library. Data show that the prolinerich dendrimers can be internalized in human epithelial (HeLa) cells, demonstrating the importance of the dendrimeric motif. The promising results described herein suggest that controlled modification of the dendrimer surface should eventually yield proline dendrimers with therapeutic potential. # 2005 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 80: 800–814, 2005 This article was originally published online as an accepted preprint. The ‘‘Published Online’ ’ date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers
Keyphrases
small library proline-based biodendrimers delivery agent dendrimer surface prolinerich dendrimers herein suggest structural modification pept sci dendrimeric motif published online date corresponds polyproline sequence preprint version wiley periodical human epithelial defined peptide dendrimers data show new type accepted preprint polymeric agent therapeutic use therapeutic potential proline dendrimers promising result
