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THE OUTCOME OF MAJOR HEPATECTOMIES FOLLOWING DIFFERENT DURATIONS OF PORTAL VEIN LIGATION IN RATS
BibTeX
@MISC{Bülbüloğlu_theoutcome,
author = {Ertan Bülbüloğlu and Mustafa Şahin and Bülent Kantarçeken and Harun Çıralık and Ali Çetinkaya and Fatma İnanç and Fikret Ezberci},
title = {THE OUTCOME OF MAJOR HEPATECTOMIES FOLLOWING DIFFERENT DURATIONS OF PORTAL VEIN LIGATION IN RATS},
year = {}
}
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Abstract
Aim: Atrophy/Hypertrophy complex constitution (AHC) by portal vein ligation (PVL) before major hepatectomies (Hx) has got beneficial effects on the functional capacity of the remnant liver tissue by increasing its volume. We aimed to evaluate whether longer duration of PVL has any additive benefit on regenaration speed, weight, biochemical, histological examination and mortality, before major hepatectomies in rats. Methods: One-hundred and twenty Wistar Albino rats were divided into four groups (PVL, PVL+Hx, Hx, Sham+Hx). Group I ( PVL), Group II ( PVL + Hx); 70 % Hx and relaparotomy after 21 days from PVL, Group III ( Hx); 70 % Hx, Group IV ( Sham + Hx); 70 % Hx after 21 days from Sham ligation. Hepatic tissue regeneration speed, weight, liver function tests and histological examination were evaluated on postoperatively 3rd, 7th, 14th and 21st days. Also, mortality rate was evaluated. Results: The regeneration speed increased in all groups except PVL+Hx. The weight of all rats decreased on postoperative 3rd day, however, then reached nearly preoperative values on 7th day and the higher values were seen on 28th day in all groups. Serum alkaline phosphatase levels increased in all groups postoperatively and decreased to normal values on postoperative
Keyphrases
pvl hx histological examination sham hx major hepatectomies group ii portal vein ligation atrophy hypertrophy complex constitution additive benefit hepatic tissue regeneration speed serum alkaline phosphatase level group iv regeneration speed liver function test mortality rate regenaration speed twenty wistar albino rat preoperative value group iii beneficial effect normal value sham ligation functional capacity remnant liver tissue
