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Phenomenological model of diffuse global and regional atrophy using finite-element methods (2006)
| Venue: | Medical Imaging, IEEE Transactions on |
| Citations: | 5 - 2 self |
BibTeX
@TECHREPORT{Camara06phenomenologicalmodel,
author = {Oscar Camara and Martin Schweiger and Rachael I. Scahill and William R. Crum and Beatrix I. Sneller and Julia A. Schnabel and Gerard R. Ridgway and David M. Cash and Derek L. G. Hill and Nick C. Fox},
title = {Phenomenological model of diffuse global and regional atrophy using finite-element methods},
institution = {Medical Imaging, IEEE Transactions on},
year = {2006}
}
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Abstract
Abstract—The main goal of this work is the generation of ground-truth data for the validation of atrophy measurement techniques, commonly used in the study of neurodegenerative diseases such as dementia. Several techniques have been used to measure atrophy in cross-sectional and longitudinal studies, but it is extremely difficult to compare their performance since they have been applied to different patient populations. Furthermore, assessment of performance based on phantom measurements or simple scaled images overestimates these techniques ’ ability to capture the complexity of neurodegeneration of the human brain. We propose a method for atrophy simulation in structural mag-netic resonance (MR) images based on finite-element methods. The method produces cohorts of brain images with known change that is physically and clinically plausible, providing data for objective evaluation of atrophy measurement techniques. Atrophy
Keyphrases
finite-element method regional atrophy phenomenological model atrophy measurement technique brain image known change simple scaled image different patient population several technique structural mag-netic resonance neurodegenerative disease atrophy simulation objective evaluation main goal phantom measurement longitudinal study technique ability ground-truth data human brain
