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Research review: the neurobiology and genetics of maltreatment and adversity (2010)
| Venue: | Journal of Child Psychology and Psychiatry |
| Citations: | 29 - 1 self |
BibTeX
@ARTICLE{Mccrory10researchreview:,
author = {Eamon Mccrory and Stephane A. De Brito and Essi Viding},
title = {Research review: the neurobiology and genetics of maltreatment and adversity},
journal = {Journal of Child Psychology and Psychiatry},
year = {2010},
pages = {1079--1095}
}
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Abstract
The neurobiological mechanisms by which childhood maltreatment heightens vulnerability to psycho-pathology remain poorly understood. It is likely that a complex interaction between environmental experiences (including poor caregiving) and an individual’s genetic make-up influence neurobiological development across infancy and childhood, which in turn sets the stage for a child’s psychological and emotional development. This review provides a concise synopsis of those studies investigating the neurobiological and genetic factors associated with childhood maltreatment and adversity. We first provide an overview of the neuroendocrine findings, drawing from animal and human studies. These studies indicate an association between early adversity and atypical development of the hypothalamic-pituitary-adrenal (HPA) axis stress response, which can predispose to psychiatric vulnerability in adulthood. We then review the neuroimaging findings of structural and functional brain differences in children and adults who have experienced childhood maltreatment. These studies offer evidence of several structural differences associated with early stress, most notably in the corpus callosum in children and the hippocampus in adults; functional studies have reported atypical activation of several brain regions, including decreased activity of the prefrontal cortex. Next we consider studies that suggest that the effect of environmental adversity may be conditional on an individual’s genotype. We also briefly consider the possible role that epigenetic mechanisms might play in mediating the impact of early adversity. Finally we consider several ways in which the neurobiological and genetic research may be relevant to clinical practice and intervention. Keywords: Child abuse, maltreatment, neuroscience, genetics, HPA, psychopathology, resilience, cortisol. There is a burgeoning interest in understanding how early adverse experiences impact on the developing brain (e.g., Caspi & Moffitt, 2006; Lupien, McEwen,
Keyphrases
childhood maltreatment research review early adversity functional study concise synopsis atypical activation atypical development several structural difference psychiatric vulnerability neuroimaging finding human study neurobiological mechanism genetic research stress response several way corpus callosum psycho-pathology remain decreased activity neuroendocrine finding several brain region early adverse experience impact child abuse genetic factor epigenetic mechanism functional brain difference individual genotype caspi moffitt possible role environmental experience prefrontal cortex emotional development clinical practice poor caregiving early stress environmental adversity complex interaction
