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MEGA5: Molecular evolutionary genetics analysis using maximum . . . (2011)
| Citations: | 7280 - 25 self |
BibTeX
@MISC{Tamura11mega5:molecular,
author = {Koichiro Tamura and Daniel Peterson and Nicholas Peterson and Glen Stecher and Masatoshi Nei and Sudhir Kumar},
title = {MEGA5: Molecular evolutionary genetics analysis using maximum . . . },
year = {2011}
}
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Abstract
Comparative analysis of molecular sequence data is essential for reconstructing the evolutionary histories of species and inferring the nature and extent of selective forces shaping the evolution of genes and species. Here, we announce the release of Molecular Evolutionary Genetics Analysis version 5 (MEGA5), which is a user-friendly software for mining online databases, building sequence alignments and phylogenetic trees, and using methods of evolutionary bioinformatics in basic biology, biomedicine, and evolution. The newest addition in MEGA5 is a collection of maximum likelihood (ML) analyses for inferring evolutionary trees, selecting best-fit substitution models (nucleotide or amino acid), inferring ancestral states and sequences (along with probabilities), and estimating evolutionary rates site-by-site. In computer simulation analyses, ML tree inference algorithms in MEGA5 compared favorably with other software packages in terms of computational efficiency and the accuracy of the estimates of phylogenetic trees, substitution parameters, and rate variation among sites. The MEGA user interface has now been enhanced to be activity driven to make it easier for the use of both beginners and experienced scientists. This version of MEGA is intended for the Windows platform, and it has been configured for effective use on Mac OS X and Linux desktops. It is available free of charge from
Keyphrases
molecular evolutionary genetics analysis phylogenetic tree sequence alignment amino acid effective use molecular evolutionary genetics analysis version best-fit substitution model maximum likelihood linux desktop basic biology evolutionary history mega user interface rate variation online database software package evolutionary tree comparative analysis evolutionary rate ancestral state computational efficiency selective force substitution parameter computer simulation analysis evolutionary bioinformatics molecular sequence data window platform experienced scientist user-friendly software inference algorithm mac o
