doi:10.1093/nar/gkr790 Sequence–structure relationships in yeast mRNAs

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doi:10.1093/nar/gkr790 Sequence–structure relationships in yeast mRNAs (2011)

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by Andrey Chursov , Mathias C. Walter , Thorsten Schmidt , Andrei Mironov , Er Shneider , Dmitrij Frishman

BibTeX

@MISC{Chursov11doi:10.1093/nar/gkr790sequence–structure,
    author = {Andrey Chursov and Mathias C. Walter and Thorsten Schmidt and Andrei Mironov and Er Shneider and Dmitrij Frishman},
    title = {doi:10.1093/nar/gkr790 Sequence–structure relationships in yeast mRNAs},
    year = {2011}
}

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Abstract

It is generally accepted that functionally important RNA structure is more conserved than sequence due to compensatory mutations that may alter the sequence without disrupting the structure. For small RNA molecules sequence–structure relationships are relatively well understood. However, structural bioinformatics of mRNAs is still in its infancy due to a virtual absence of experimental data. This report presents the first quantitative assessment of sequence–structure divergence in the coding regions of mRNA molecules based on recently published transcriptome-wide experimental determination of their base paring patterns. Structural resemblance in paralogous mRNA pairs quickly

Keyphrases

yeast mrna nar gkr790 sequence structure relationship structural resemblance structural bioinformatics mrna molecule experimental data transcriptome-wide experimental determination compensatory mutation paralogous mrna pair base paring pattern virtual absence first quantitative assessment important rna structure sequence structure divergence coding region

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