DMCA
Staphylococcus aureus
BibTeX
@MISC{Mastitis_staphylococcusaureus,
author = {Postpartum Mastitis and Communityacquired and Pavani Reddy and Chao Qi and Teresa Zembower and Gary A. Noskin and Maureen Bolon},
title = {Staphylococcus aureus},
year = {}
}
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Abstract
This single-center, case-control study documents a relative increase in methicillin resistance among 48 cases of Staphylococcus aureus–associated postpartum mastitis during 1998–2005. Of 21 cases with methicillin resistance, 17 (81%) occurred in 2005. Twenty (95%) isolates contained the Staphylococcus cassette chromosome mec type IV gene; this suggests that the increase is due to community-acquired methicillin-resistant S.aureus. Postpartum mastitis (PPM) occurs in as many as one third of breastfeeding women in the United States and leads to breast abscess formation in ≈10 % of cases (1,2). Although breast milk cultures are not routine in PPM management, the growth of potentially pathogenic bacteria (such as β-hemolytic streptococci or Staphylococcus aureus) is associated with longer time to recovery and more frequent abscess formation (3). S. aureus is the most common bacterium isolated from such cultures, representing 37%–50 % of isolates (4,5). Reports of methicillin-resistant S. aureus (MRSA) PPM among young, healthy women lacking traditional risk factors for MRSA have emerged in the past few years (6,7). Isolates in these cases of community-acquired infection (CA-MRSA) remain susceptible to multiple non–β-lactam antibiotics and possess distinct molecular features (8). Although risk factors associated with skin and soft tissue infections due to CA-MRSA have been described (8,9), characteristics unique to patients with CA-MRSA PPM are unknown. To identify risk factors, complications, and outcomes among patients with CA-MRSA PPM, we conducted a retrospective, case-control study to include all S. aureus–associated cases at a single institution over an 8-year period. MRSA isolates were analyzed by PCR for the presence of the Staphylococcus cassette chromosome *Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA (SCC) mec type IV gene, which is commonly associated with community-acquired infection.
Keyphrases
staphylococcus aureus postpartum mastitis risk factor community-acquired infection methicillin resistance ca-mrsa ppm single institution posse distinct molecular feature breast milk culture healthy woman common bacterium pathogenic bacteria traditional risk factor past year frequent abscess formation ppm management relative increase mrsa isolates abscess formation hemolytic streptococci case-control study community-acquired methicillin-resistant mec type iv gene soft tissue infection 8-year period case-control study document united state non lactam antibiotic
