DMCA
SUV in head and neck cancer
BibTeX
@MISC{Staging_suvin,
author = {Fdg-pet Staging and Gregory J Kubicek and Collin Champ and Shannon Fogh and Fen Wang and Eashwer Reddy and Charles Intenzo and Reginald W Dusing and Mitchell Machtay},
title = {SUV in head and neck cancer},
year = {}
}
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Abstract
Objectives: The role of positron emission tomography (PET) with fluoro-deoxy-glucose (FDG) in the staging of head and neck cancer (HNC) is unclear. The NCCN guidelines do not recommend FDG-PET as a part of standard workup. The purpose of this report is to examine the role of FDG-PET imaging in altering management and providing prognostic information for HNC. Methods: Retrospective review of HNC patients who had a staging FDG-PET scan performed at either Thomas Jefferson University or University of Kansas Medical Center between the years 2001 and 2007. A total of 212 PET scans were performed in patients who went on to receive radiotherapy. Results: The median follow-up time for all patients was 469 days. The PPV and NPV of PET imaging to correctly identify lymph node status was 94 % and 89 % respectively. Lymph nodes with extracapsular extension (ECE) had higher SUVs than nodes without ECE, 11.0 vs. 5.0 (p < 0.0007). Maximum SUV for the primary tumor> 8.0 was predictive of worse overall survival (p < 0.045), while the SUV of the lymph nodes was predictive for distant recurrence at one year–with a mean SUV value of 10.4 for patients with distant failure vs. 7.0 without (p < 0.05). Conclusions: FDG-PET staging in head and neck cancer has good positive and negative predictive values in determining lymph node status. The maximum SUV of the primary tumor is predictive of overall survival. This is the first report to find that the SUV of a lymph node is predictive for ECE and also for distant recurrence.
Keyphrases
neck cancer primary tumor maximum suv overall survival distant recurrence lymph node lymph node status distant failure v fdg-pet imaging hnc patient nccn guideline retrospective review staging fdg-pet scan prognostic information first report positron emission tomography median follow-up time negative predictive value thomas jefferson university standard workup mean suv value fdg-pet staging pet scan extracapsular extension kansa medical center
